Influence of gut microbiota on systemic immune responses and cancer immunotherapy

Swathi P. Murakonda; Sahasra Balusu; Haritha Chava; Ajay B. Murakonda; Reshmi Polneedi; Sushanth Bodduluri; Subash C. Gupta; Kishore B. Challagundla

doi:10.1016/bs.ircmb.2024.12.005

Influence of gut microbiota on systemic immune responses and cancer immunotherapy

Swathi P. Murakonda, Sahasra Balusu, Haritha Chava, Ajay B. Murakonda, Reshmi Polneedi, Sushanth Bodduluri, Subash C. Gupta, Kishore B. Challagundla

Research output: Contribution to journal › Article › peer-review

Abstract

The gut microbiota is increasingly being recognized as a key player in the onset and progression of several human diseases, including malignancies. Recent research has shed light on the complex relationships between the gut microbiome and the effectiveness of cancer immunotherapy. Gaining a thorough understanding of how the gut microbiota influences immune responses during cancer treatments is critical for medical advancements. This review aims to delve into the intricate interactions between gut microbiota, the systemic immune system, and cancer immunotherapy. Additionally, as the gut microbiota can contribute to immune-related adverse effects, we explored possible interventions to alleviate these side effects and reviewed microbiota-targeted strategies that could enhance the success of cancer immunotherapies.

Original language	English (US)
Journal	International Review of Cell and Molecular Biology
DOIs	https://doi.org/10.1016/bs.ircmb.2024.12.005
State	Accepted/In press - 2025

Keywords

Chemotherapy response
Gut Microbiota
Immune cells
Immunotherapy

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/bs.ircmb.2024.12.005

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title = "Influence of gut microbiota on systemic immune responses and cancer immunotherapy",

abstract = "The gut microbiota is increasingly being recognized as a key player in the onset and progression of several human diseases, including malignancies. Recent research has shed light on the complex relationships between the gut microbiome and the effectiveness of cancer immunotherapy. Gaining a thorough understanding of how the gut microbiota influences immune responses during cancer treatments is critical for medical advancements. This review aims to delve into the intricate interactions between gut microbiota, the systemic immune system, and cancer immunotherapy. Additionally, as the gut microbiota can contribute to immune-related adverse effects, we explored possible interventions to alleviate these side effects and reviewed microbiota-targeted strategies that could enhance the success of cancer immunotherapies.",

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language = "English (US)",

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AU - Murakonda, Swathi P.

AU - Balusu, Sahasra

AU - Chava, Haritha

AU - Murakonda, Ajay B.

AU - Polneedi, Reshmi

AU - Bodduluri, Sushanth

AU - Gupta, Subash C.

AU - Challagundla, Kishore B.

PY - 2025

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N2 - The gut microbiota is increasingly being recognized as a key player in the onset and progression of several human diseases, including malignancies. Recent research has shed light on the complex relationships between the gut microbiome and the effectiveness of cancer immunotherapy. Gaining a thorough understanding of how the gut microbiota influences immune responses during cancer treatments is critical for medical advancements. This review aims to delve into the intricate interactions between gut microbiota, the systemic immune system, and cancer immunotherapy. Additionally, as the gut microbiota can contribute to immune-related adverse effects, we explored possible interventions to alleviate these side effects and reviewed microbiota-targeted strategies that could enhance the success of cancer immunotherapies.

AB - The gut microbiota is increasingly being recognized as a key player in the onset and progression of several human diseases, including malignancies. Recent research has shed light on the complex relationships between the gut microbiome and the effectiveness of cancer immunotherapy. Gaining a thorough understanding of how the gut microbiota influences immune responses during cancer treatments is critical for medical advancements. This review aims to delve into the intricate interactions between gut microbiota, the systemic immune system, and cancer immunotherapy. Additionally, as the gut microbiota can contribute to immune-related adverse effects, we explored possible interventions to alleviate these side effects and reviewed microbiota-targeted strategies that could enhance the success of cancer immunotherapies.

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KW - Gut Microbiota

KW - Immune cells

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Influence of gut microbiota on systemic immune responses and cancer immunotherapy

Abstract

Keywords

ASJC Scopus subject areas

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