Influence of projected complication rates on estimated appropriate use rates for carotid endarterectomy

David B. Matchar, Eugene Z. Oddone, Douglas C. McCrory, Larry B. Goldstein, Pamela B. Landsman, Greg Samsa, Robert H. Brook, Caren Kamberg, Lee Hilborne, Lucian Leape, Ronnie Horner

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective. To examine specifically the influence of estimated perioperative mortality and stroke rate on the assessment of appropriateness of carotid endarterectomy. Data Sources/Study Setting. An expert panel convened to rate the appropriateness of a variety of potential indications for carotid endarterectomy based on various rates of perioperative complications. We then applied these ratings to the charts of 1,160 randomly selected patients who had carotid endarterectomy in one of the 12 participating academic medical centers. Study Design. An expert panel evaluated indications for carotid endarterectomy using the modified Delphi approach. Charts of patients who received surgery were abstracted, and clinical indications for the procedure as well as perioperative complications were recorded. To examine the impact of surgical risk assessment on the rates of appropriateness, three different definitions of risk strata for combined perioperative death or stroke were used: Definition A, low risk <3 percent; Definition B, low risk <5 percent; and Definition C, low risk <7 percent. Principal Findings. Overall hospital-specific mortality ranged from 0 percent to 4.0 percent and major complications, defined as death, stroke, intracranial hemorrhage, or myocardial infarction, varied from 2.0 percent to 11.1 percent. Most patients (72 percent) had surgery for transient ischemic attack or stroke; 24 percent of patients were asymptomatic. Most patients (82 percent) had surgery on the side of a high-grade stenosis (70-99 percent). When the thresholds for operative risk were placed at the values defined by the expert panel (Definition A), only 33.5 percent of 1,160 procedures were classified as 'appropriate.' When the definition of low risk was shifted upward, the proportion of cases categorized as appropriate increased to 58 percent and 81.5 percent for Definitions B and C, respectively. Conclusions. Despite the high proportion of procedures performed for symptomatic patients with a high degree of ipsilateral extracranial carotid artery stenosis and generally low rates of surgical complications at the participating institutions, the overall rate of 'appropriateness' using a perioperative complication rate of <3 percent was low. However, the rate of 'appropriateness' was extremely sensitive to judgments about a single clinical feature, surgical risk. These data show that before applying such 'appropriateness' ratings, it is crucial to perform sensitivity analyses in order to assess the stability of the results. Results that are robust to moderate in variation in surgical risk provide a much sounder basis for policymaking than those that are not.

Original languageEnglish (US)
Pages (from-to)325-342
Number of pages18
JournalHealth Services Research
Issue number3
StatePublished - Aug 1997
Externally publishedYes


  • Carotid artery diseases
  • Cerebrovascular disorders
  • Endarterectomy
  • Physicians' practice patterns
  • Utilization review

ASJC Scopus subject areas

  • Health Policy


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