Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis

Yutong Liu, Mariano G. Uberti, Huanyu Dou, Rebecca Banerjee, Cassi B. Grotepas, David K. Stone, Barrett E. Rabinow, Howard E. Gendelman, Michael D. Boska

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Blood-borne macrophage ingress into brain in HIV-1 associated neurocognitive disorders governs the tempo of disease. We used superparamagnetic iron-oxide particles loaded into murine bone marrow-derived macrophages (BMM) injected intravenously into HIV-1 encephalitis mice to quantitatively assess BMM entry into diseased brain regions. Magnetic resonance imaging tests were validated by histological coregistration and enhanced image processing. The demonstration of robust BMM migration into areas of focal encephalitis provide 'proof of concept' for the use of MRI to monitor macrophage ingress into brain.

Original languageEnglish (US)
Pages (from-to)41-52
Number of pages12
JournalJournal of Neuroimmunology
Volume200
Issue number1-2
DOIs
StatePublished - Aug 30 2008

Keywords

  • Blood-brain barrier
  • HIV-1 encephalitis
  • Image coregistration
  • Monocyte-derived macrophages

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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