Inheritance of a mutation causing neuropathy with splayed forelimbs in Jersey cattle

A. Al-Khudhair, D. J. Null, J. B. Cole, C. W. Wolfe, D. J. Steffen, P. M. VanRaden

Research output: Contribution to journalArticlepeer-review

Abstract

A new undesirable genetic factor, neuropathy with splayed forelimbs (JNS), has been identified recently in the Jersey breed. Calves affected with JNS are unable to stand on splayed forelimbs that exhibit significant extensor rigidity and excessive lateral abduction at birth. Affected calves generally are alert at birth but exhibit neurologic symptoms, including spasticity of head and neck and convulsive behavior. Other symptoms reported include dislocated shoulders, congenital craniofacial anomalies, and degenerative myelopathy. Inheritance of an undesirable genetic factor was determined from a study of 16 affected calves reported by Jersey breeders across the United States. All of their pedigrees traced back on both paternal and maternal sides to a common ancestor born in 1995. Genotypes revealed that JNS is attributable to a specific haplotype on Bos taurus autosome 6. Currently 8.2% of the genotyped US Jersey population are carriers of the haplotype. Sequencing of the region of shared homozygosity revealed missense variant rs1116058914 at base 60,158,901 of the ARS-UCD1.2 reference map as the most concordant with the genetic condition and the most likely cause. The single-base G to A substitution is in the coding region of the last exon of UCHL1, which is conserved across species. Mutations in humans and gene knockouts in mice cause similar recessive symptoms and muscular degeneration. Since December 2020, carrier status has been tracked using the identified haplotype and reported for all 459,784 genotyped Jersey animals. With random mating, about 2,200 affected calves per year with losses of about $250,000 would result from the 1.3 million US Jersey cows in the national population. Selection and mating programs can reduce numbers of JNS-affected births using either the haplotype status or a direct gene test in the future. Breeders should report calf abnormalities to their breed association to help discover new defects such as JNS.

Original languageEnglish (US)
Pages (from-to)1338-1345
Number of pages8
JournalJournal of Dairy Science
Volume105
Issue number2
DOIs
StatePublished - Feb 2022

Keywords

  • Jersey neuropathy with splayed forelimbs (JNS)
  • UCHL1
  • carrier
  • genetic defect
  • lethal recessive

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

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