TY - JOUR
T1 - Inherited partial trisomy #15 complicated by neuroblastoma
AU - Sanger, Warren G.
AU - Howe, Janet
AU - Fordyce, Renee
AU - Purtilo, David T.
N1 - Funding Information:
Supportedin part by NIH Grant CA-30196,A CS Grant RD161, the NebraskaC igaretteT ax LB506, the NebraskaD epartmenotf Health, and the U.S. Departmenotf Health and Human Resources.
PY - 1984/2
Y1 - 1984/2
N2 - The proband in this study had multiple congenital malformations and a constitutional 46,XY,-13,+der(13),t(13;15)(q34;q23)mat chromosome complement. A bone marrow aspirate revealed neuroblastoma, and cytogenetic studies on tumor cells revealed, in addition to the partial trisomy #15 and probable partial monosomy #13, hypotetraploidy with a mean chromosome number of 82-84, including 3 or 4 copies of each autosome, 2 X chromosomes, no Y chromosome, and a marker. Translocations involving chromosomes #1, #2, #3, #7, and #14 were present, along with multiple double minutes. The possibility that the inherited partial trisomy #15 (and/or partial chromosome #13 monosomy) predisposed to neuroblastoma and additional chromosome changes in this tumor is discussed.
AB - The proband in this study had multiple congenital malformations and a constitutional 46,XY,-13,+der(13),t(13;15)(q34;q23)mat chromosome complement. A bone marrow aspirate revealed neuroblastoma, and cytogenetic studies on tumor cells revealed, in addition to the partial trisomy #15 and probable partial monosomy #13, hypotetraploidy with a mean chromosome number of 82-84, including 3 or 4 copies of each autosome, 2 X chromosomes, no Y chromosome, and a marker. Translocations involving chromosomes #1, #2, #3, #7, and #14 were present, along with multiple double minutes. The possibility that the inherited partial trisomy #15 (and/or partial chromosome #13 monosomy) predisposed to neuroblastoma and additional chromosome changes in this tumor is discussed.
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U2 - 10.1016/0165-4608(84)90109-2
DO - 10.1016/0165-4608(84)90109-2
M3 - Article
C2 - 6692336
AN - SCOPUS:0021345569
SN - 0165-4608
VL - 11
SP - 153
EP - 159
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 2
ER -