Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia

D. Lekieffre; O. Ghribi; J. Callebert; M. Allix; M. Plotkine; R. G. Boulu

doi:10.1016/0006-8993(92)91693-9

Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia

D. Lekieffre, O. Ghribi, J. Callebert, M. Allix, M. Plotkine, R. G. Boulu

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/kg) on ischemia-induced hippocampal glutamate release and neuronal damage. Kynurenic acid significantly decreased glutamate release during ischemia but had no effect on the hippocampal lesion. Some protection was observed in the cortex and in the striatum. These data suggested that the extracellular accumulation of glutamate during forebrain ischemia does not play a major role in the hippocampus.

Original language	English (US)
Pages (from-to)	333-337
Number of pages	5
Journal	Brain Research
Volume	592
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(92)91693-9
State	Published - Oct 2 1992
Externally published	Yes

Keywords

Forebrain ischemia
Glutamate
Hippocampus
Kynurenic acid
Microdialysis
Neuronal death
Rat

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(92)91693-9

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abstract = "We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/kg) on ischemia-induced hippocampal glutamate release and neuronal damage. Kynurenic acid significantly decreased glutamate release during ischemia but had no effect on the hippocampal lesion. Some protection was observed in the cortex and in the striatum. These data suggested that the extracellular accumulation of glutamate during forebrain ischemia does not play a major role in the hippocampus.",

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author = "D. Lekieffre and O. Ghribi and J. Callebert and M. Allix and M. Plotkine and Boulu, {R. G.}",

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AU - Lekieffre, D.

AU - Ghribi, O.

AU - Callebert, J.

AU - Allix, M.

AU - Plotkine, M.

AU - Boulu, R. G.

PY - 1992/10/2

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N2 - We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/kg) on ischemia-induced hippocampal glutamate release and neuronal damage. Kynurenic acid significantly decreased glutamate release during ischemia but had no effect on the hippocampal lesion. Some protection was observed in the cortex and in the striatum. These data suggested that the extracellular accumulation of glutamate during forebrain ischemia does not play a major role in the hippocampus.

AB - We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/kg) on ischemia-induced hippocampal glutamate release and neuronal damage. Kynurenic acid significantly decreased glutamate release during ischemia but had no effect on the hippocampal lesion. Some protection was observed in the cortex and in the striatum. These data suggested that the extracellular accumulation of glutamate during forebrain ischemia does not play a major role in the hippocampus.

KW - Forebrain ischemia

KW - Glutamate

KW - Hippocampus

KW - Kynurenic acid

KW - Microdialysis

KW - Neuronal death

KW - Rat

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Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia

Abstract

Keywords

ASJC Scopus subject areas

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