Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate

L. Guo, N. K. Heinzinger, M. Stevenson, L. M. Schopfer, J. M. Salhany

Research output: Contribution to journalComment/debate

11 Scopus citations

Abstract

Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine- reactive and anionic substituents.

Original languageEnglish (US)
Pages (from-to)2483-2487
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume38
Issue number10
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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