Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate

L. Guo; N. K. Heinzinger; M. Stevenson; L. M. Schopfer; J. M. Salhany

doi:10.1128/AAC.38.10.2483

Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate

L. Guo, N. K. Heinzinger, M. Stevenson, L. M. Schopfer, J. M. Salhany

Eppley Institute for Cancer Research

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

Abstract

Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine- reactive and anionic substituents.

Original language	English (US)
Pages (from-to)	2483-2487
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	38
Issue number	10
DOIs	https://doi.org/10.1128/AAC.38.10.2483
State	Published - 1994

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine- reactive and anionic substituents.",

author = "L. Guo and Heinzinger, {N. K.} and M. Stevenson and Schopfer, {L. M.} and Salhany, {J. M.}",

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AU - Guo, L.

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AU - Stevenson, M.

AU - Schopfer, L. M.

AU - Salhany, J. M.

PY - 1994

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N2 - Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine- reactive and anionic substituents.

AB - Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine- reactive and anionic substituents.

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Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate

Abstract

ASJC Scopus subject areas

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