Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat

Verner S. Westerberg; Jonathan D. Geiger

doi:10.1016/0091-3057(87)90464-3

Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat

Verner S. Westerberg, Jonathan D. Geiger

Great Plains IDeA-CTR

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.

Original language	English (US)
Pages (from-to)	419-422
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(87)90464-3
State	Published - Nov 1987

Keywords

Gastric acid
Gastric ulcers
Histidine decarboxylase
Inhibitors

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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Westerberg, V. S., & Geiger, J. D. (1987). Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat. Pharmacology, Biochemistry and Behavior, 28(3), 419-422. https://doi.org/10.1016/0091-3057(87)90464-3

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