TY - JOUR
T1 - Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat
AU - Westerberg, Verner S.
AU - Geiger, Jonathan D.
N1 - Funding Information:
We w~sh to thank Dr G B Glawn for h~s adwce, Dr J Kol-lomtsch (Merck Sharp and Dohme, Rahway, N J) for generous gifts of FMHd and FMHm, Ms K Klernan for technical assistance and Ms B Hunt for typing the manuscnpt This work was supported by grants from the Medical Research Council of Canada (MRCC) and Mamtoba Health Research Councd VSW is a post-doctoral Fellow of the St Boniface General Hospital Research Foundation and JDG ~s a Scholar of MRCC
PY - 1987/11
Y1 - 1987/11
N2 - We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.
AB - We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.
KW - Gastric acid
KW - Gastric ulcers
KW - Histidine decarboxylase
KW - Inhibitors
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U2 - 10.1016/0091-3057(87)90464-3
DO - 10.1016/0091-3057(87)90464-3
M3 - Article
C2 - 3685079
AN - SCOPUS:0023469708
SN - 0091-3057
VL - 28
SP - 419
EP - 422
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 3
ER -