Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat

Verner S. Westerberg, Jonathan D. Geiger

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.

Original languageEnglish (US)
Pages (from-to)419-422
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume28
Issue number3
DOIs
StatePublished - Nov 1987

Keywords

  • Gastric acid
  • Gastric ulcers
  • Histidine decarboxylase
  • Inhibitors

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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