Abstract
We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.
Original language | English (US) |
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Pages (from-to) | 419-422 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 28 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1987 |
Externally published | Yes |
Keywords
- Gastric acid
- Gastric ulcers
- Histidine decarboxylase
- Inhibitors
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience