Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat

Verner S. Westerberg; Jonathan D. Geiger

doi:10.1016/0091-3057(87)90464-3

Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat

Verner S. Westerberg, Jonathan D. Geiger

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.

Original language	English (US)
Pages (from-to)	419-422
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/0091-3057(87)90464-3
State	Published - Nov 1987
Externally published	Yes

Keywords

Gastric acid
Gastric ulcers
Histidine decarboxylase
Inhibitors

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(87)90464-3

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title = "Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat",

abstract = "We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.",

keywords = "Gastric acid, Gastric ulcers, Histidine decarboxylase, Inhibitors",

author = "Westerberg, {Verner S.} and Geiger, {Jonathan D.}",

note = "Funding Information: We w~sh to thank Dr G B Glawn for h~s adwce, Dr J Kol-lomtsch (Merck Sharp and Dohme, Rahway, N J) for generous gifts of FMHd and FMHm, Ms K Klernan for technical assistance and Ms B Hunt for typing the manuscnpt This work was supported by grants from the Medical Research Council of Canada (MRCC) and Mamtoba Health Research Councd VSW is a post-doctoral Fellow of the St Boniface General Hospital Research Foundation and JDG ~s a Scholar of MRCC",

year = "1987",

month = nov,

doi = "10.1016/0091-3057(87)90464-3",

language = "English (US)",

volume = "28",

pages = "419--422",

journal = "Pharmacology Biochemistry and Behavior",

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number = "3",

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TY - JOUR

T1 - Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat

AU - Westerberg, Verner S.

AU - Geiger, Jonathan D.

N1 - Funding Information: We w~sh to thank Dr G B Glawn for h~s adwce, Dr J Kol-lomtsch (Merck Sharp and Dohme, Rahway, N J) for generous gifts of FMHd and FMHm, Ms K Klernan for technical assistance and Ms B Hunt for typing the manuscnpt This work was supported by grants from the Medical Research Council of Canada (MRCC) and Mamtoba Health Research Councd VSW is a post-doctoral Fellow of the St Boniface General Hospital Research Foundation and JDG ~s a Scholar of MRCC

PY - 1987/11

Y1 - 1987/11

N2 - We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.

AB - We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-α-fluoromethylhistidine (FMHd) and (s)-α-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesserdegree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.

KW - Gastric acid

KW - Gastric ulcers

KW - Histidine decarboxylase

KW - Inhibitors

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U2 - 10.1016/0091-3057(87)90464-3

DO - 10.1016/0091-3057(87)90464-3

M3 - Article

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AN - SCOPUS:0023469708

VL - 28

SP - 419

EP - 422

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -

Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat

Abstract

Keywords

ASJC Scopus subject areas

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