Inhibitory effect of 6 beta-acetoxy nortropane on respiration

B. Yao, J. L. Zheng, W. Qin, C. F. Bian

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


6 beta-AN (6 beta-acetoxy nortropane), a novel selective M2-receptor agonist, caused decrease in FR, TV, MVV and pO2 and increase of pCO2 when intravenous injection of 10 in conscious rabbits or 2, 5, 20 in conscious dogs was given (P < 0.05 or 0.01). The inhibitory effect on MVV exhibited a dose-dependent relationship. Small doses of 6 beta-AN icv (0.5, 1, 2, 4 in the conscious rabbits) and iva (0.25, 0.5 and 1.0 in anesthetized dogs) decreased FR, TV, MVV and pO2 and increased pCO2 as well. These results were reversed after administration of AF-DX116 and enhanced after administration of pirenzepine. Thus, it appears that the inhibitory action of 6 beta-AN on respiration might be related to stimulation of the inhibitory M2 cholinergic receptor in respiratory center.

Original languageEnglish (US)
Pages (from-to)497-501
Number of pages5
JournalYao xue xue bao = Acta pharmaceutica Sinica
Issue number7
StatePublished - 1994

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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