Abstract
6 beta-AN (6 beta-acetoxy nortropane), a novel selective M2-receptor agonist, caused decrease in FR, TV, MVV and pO2 and increase of pCO2 when intravenous injection of 10 micrograms.kg-1 in conscious rabbits or 2, 5, 20 micrograms.kg-1 in conscious dogs was given (P < 0.05 or 0.01). The inhibitory effect on MVV exhibited a dose-dependent relationship. Small doses of 6 beta-AN icv (0.5, 1, 2, 4 micrograms.kg-1 in the conscious rabbits) and iva (0.25, 0.5 and 1.0 micrograms.kg-1 in anesthetized dogs) decreased FR, TV, MVV and pO2 and increased pCO2 as well. These results were reversed after administration of AF-DX116 and enhanced after administration of pirenzepine. Thus, it appears that the inhibitory action of 6 beta-AN on respiration might be related to stimulation of the inhibitory M2 cholinergic receptor in respiratory center.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 497-501 |
| Number of pages | 5 |
| Journal | Yao xue xue bao = Acta pharmaceutica Sinica |
| Volume | 29 |
| Issue number | 7 |
| State | Published - 1994 |
| Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)