Initial and subsequent cytogenetic studies in malignant lymphoma

W. G. Sanger, James O. Armitage, J. Bridge, Dennis D. Weisenburger, Renee Fordyce, David T. Purtilo

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Two or more cytogenetic studies of lymph node biopsy specimens from 12 patients with non–Hodgkin's malignant lymphoma were performed. Each of the 12 patients had at least one clonal structural chromosome abnormality in their initial biopsy specimen. A comparison of the chromosome abnormalities in the initial lymph node biopsy specimens with those in subsequent biopsy specimens was made. Structural and numerical chromosome changes were not always accompanied by a change in the histologic type of the lymphoma. Similarly, a change in histologic type was not always associated with the appearance of new structural or numerical abnormalities. Serial cytogenetic studies from additional patients will further our understanding relevant to which chromosome changes are associated with lymphomagenesis and which are secondary or more of an evolutionary nature.

Original languageEnglish (US)
Pages (from-to)3014-3019
Number of pages6
JournalCancer
Volume60
Issue number12
DOIs
StatePublished - Dec 15 1987

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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