Innate immunity and autoimmunity: From self-protection to self-destruction

Fu Dong Shi, Hans Gustaf Ljunggren, Nora Sarvetnick

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations


Innate immune responses provide the body with its first line of defense against infections. Signals generated by a subset of lymphocytes, including natural killer (NK) cells and natural killer T (NKT) cells, during the early host response might have an additional role in determining the nature of downstream adaptive immune responses. Here, Fu-Dong Shi, Hans-Gustaf Ljunggren and Nora Sarvetnick discuss the role of cellular and soluble components of innate immunity in the development of autoimmune diseases. Some putative pathways leading from innate immunity to autoimmunity are proposed.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalTrends in Immunology
Issue number2
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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