TY - JOUR
T1 - Innate immunity and autoimmunity
T2 - From self-protection to self-destruction
AU - Shi, Fu Dong
AU - Ljunggren, Hans Gustaf
AU - Sarvetnick, Nora
N1 - Funding Information:
We thank members of our groups for fruitful discussions, and P. Minick and B. Elckmen for editorial assistance. F-D.S. is supported by the Swedish Medical Research Council and the Juvenile Diabetes Foundation International (JDFI). H-G.L. is supported by the Swedish Medical Research Council, the Swedish Cancer Society and the Karolinska Institute. N.S. is supported by grants from the JDFI and the NIH. We apologize to the many authors in this field that not all relevant references could be cited because of space constraints. This is manuscript number 13346-IMM from The Scripps Research Institute.
PY - 2001
Y1 - 2001
N2 - Innate immune responses provide the body with its first line of defense against infections. Signals generated by a subset of lymphocytes, including natural killer (NK) cells and natural killer T (NKT) cells, during the early host response might have an additional role in determining the nature of downstream adaptive immune responses. Here, Fu-Dong Shi, Hans-Gustaf Ljunggren and Nora Sarvetnick discuss the role of cellular and soluble components of innate immunity in the development of autoimmune diseases. Some putative pathways leading from innate immunity to autoimmunity are proposed.
AB - Innate immune responses provide the body with its first line of defense against infections. Signals generated by a subset of lymphocytes, including natural killer (NK) cells and natural killer T (NKT) cells, during the early host response might have an additional role in determining the nature of downstream adaptive immune responses. Here, Fu-Dong Shi, Hans-Gustaf Ljunggren and Nora Sarvetnick discuss the role of cellular and soluble components of innate immunity in the development of autoimmune diseases. Some putative pathways leading from innate immunity to autoimmunity are proposed.
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U2 - 10.1016/S1471-4906(00)01821-4
DO - 10.1016/S1471-4906(00)01821-4
M3 - Review article
C2 - 11286711
AN - SCOPUS:0034919647
SN - 1471-4906
VL - 22
SP - 97
EP - 101
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -