Innate lymphocytes: Role in alcohol-induced immune dysfunction

Karla Ruiz-Cortes, Daniel N. Villageliu, Derrick R. Samuelson

Research output: Contribution to journalReview articlepeer-review

Abstract

Alcohol use is known to alter the function of both innate and adaptive immune cells, such as neutrophils, macrophages, B cells, and T cells. Immune dysfunction has been associated with alcohol-induced end-organ damage. The role of innate lymphocytes in alcohol-associated pathogenesis has become a focus of research, as liver-resident natural killer (NK) cells were found to play an important role in alcohol-associated liver damage pathogenesis. Innate lymphocytes play a critical role in immunity and homeostasis; they are necessary for an optimal host response against insults including infections and cancer. However, the role of innate lymphocytes, including NK cells, natural killer T (NKT) cells, mucosal associated invariant T (MAIT) cells, gamma delta T cells, and innate lymphoid cells (ILCs) type 1–3, remains ill-defined in the context of alcohol-induced end-organ damage. Innate-like B lymphocytes including marginal zone B cells and B-1 cells have also been identified; however, this review will address the effects of alcohol misuse on innate T lymphocytes, as well as the consequences of innate T-lymphocyte dysfunction on alcohol-induced tissue damage.

Original languageEnglish (US)
Article number934617
JournalFrontiers in immunology
Volume13
DOIs
StatePublished - Aug 29 2022

Keywords

  • alcohol
  • bacteria
  • innate immunity
  • innate lymphocytes
  • pneumonia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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