Insights into the distinct cooperation between the transcription factor Clp and LeDSF signaling in the regulation of antifungal factors in Lysobacter enzymogenes OH11

Gaoge Xu, Xiaofeng Shi, Ruping Wang, Huiyong Xu, Liangcheng Du, Shan Ho Chou, Hongxia Liu, Youzhou Liu, Guoliang Qian, Fengquan Liu

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The DSF (Diffusible Signal Factor) signaling and transcription factor Clp play key roles in regulating a diverse range of physiology in the phytopathogen Xanthomonas campestris pv. campestris. However, their functional relationship in other bacteria is little addressed. Here, we presented evidences to show that there are distinct differences in signaling connection between the Clp and LeDSF pathways in Lysobacter enzymogenes, which is a Gram-negative bacterium with remarkable antifungal activity. We found that Clp was a bona fide regulator downstream of the LeDSF signaling in modulating HSAF biosynthesis. However, regulations of Clp on the other two processes, namely, the extracellular protease and chitinase productions, as well as twitching motility, were found to be independent of the LeDSF signaling. These distinct behaviors of Clp were further validated by a comprehensive transcriptomic analysis. Taken together, the present study expands our understanding on the connection between the DSF signaling and Clp signaling pathways in different bacteria.

Original languageEnglish (US)
Pages (from-to)52-58
Number of pages7
JournalBiological Control
Volume120
DOIs
StatePublished - May 2018

Keywords

  • Biocontrol
  • Clp
  • LeDSF
  • Lysobacter enzymogenes
  • Signaling

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Insect Science

Fingerprint Dive into the research topics of 'Insights into the distinct cooperation between the transcription factor Clp and LeDSF signaling in the regulation of antifungal factors in Lysobacter enzymogenes OH11'. Together they form a unique fingerprint.

  • Cite this