TY - JOUR
T1 - Insights into the neurodegenerative process of Alzheimer's disease
T2 - A role for mononuclear phagocyte-associated inflammation and neurotoxicity
AU - Cotter, Robin L.
AU - Burke, William J.
AU - Thomas, Vince S.
AU - Potter, Jane F.
AU - Zheng, Jialin
AU - Gendelman, Howard E.
PY - 1999
Y1 - 1999
N2 - Since the first description of Alzheimer's disease (AD) in 1907, significant progress was made into understanding disease pathophysiology. The enormous effort in AD research has translated into the discovery of genetic linkages for disease, into elucidating the structure and function of the etiologic β-amyloid protein, and into unraveling the seemingly complex neuroimmunological cascade that affects neuronal dysfunction. Although effective therapies do not currently exist, many are being developed. We propose that the neuropathogenesis of AD, in measure, revolves around the immunological activation of glial cells, which in turn leads to alterations in inflammatory neurotoxin production, and ultimately to neuronal injury and death. Elucidating the mechanisms involved in such glial cell immune activation should provide valuable insights into understanding the disease process and in providing effective therapeutics to prevent and/or retard the devastating neurodegeneration that afflicts so many of our elderly.
AB - Since the first description of Alzheimer's disease (AD) in 1907, significant progress was made into understanding disease pathophysiology. The enormous effort in AD research has translated into the discovery of genetic linkages for disease, into elucidating the structure and function of the etiologic β-amyloid protein, and into unraveling the seemingly complex neuroimmunological cascade that affects neuronal dysfunction. Although effective therapies do not currently exist, many are being developed. We propose that the neuropathogenesis of AD, in measure, revolves around the immunological activation of glial cells, which in turn leads to alterations in inflammatory neurotoxin production, and ultimately to neuronal injury and death. Elucidating the mechanisms involved in such glial cell immune activation should provide valuable insights into understanding the disease process and in providing effective therapeutics to prevent and/or retard the devastating neurodegeneration that afflicts so many of our elderly.
KW - Apoptosis
KW - Central nervous system
KW - Complement
KW - Immunopathology
KW - Mononuclear phagocytes
KW - Neurotrophins
KW - Pro-inflammatory cytokines
KW - Signal transduction
KW - β- amyloid protein
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U2 - 10.1002/jlb.65.4.416
DO - 10.1002/jlb.65.4.416
M3 - Review article
C2 - 10204569
AN - SCOPUS:0032925694
SN - 0741-5400
VL - 65
SP - 416
EP - 427
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
IS - 4
ER -