Instrumentation and Process Control

Mark Riley

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Cultivation of animal cells in an environment optimal for manufacture of desired products requires monitoring and control of a substantial number of physical and chemical parameters. Physical parameters include temperature, fluid flow, and agitation rates. Chemical parameters include the dissolved oxygen (DO) concentration, pH, cell density, and the concentrations of nutrients, cofactors, growth factors, desired products, and wastes. Alterations in the levels of these factors can impact the productivity of a cultivation. Neglecting any of these can potentially introduce substantial variations in the quantity or quality of the desired product. Development of instrumentation to monitor these parameters and to provide aggressive process control schemes has been the subject of substantial research in recent years and now forms a core competency of cell culture technology. This chapter provides an overview of instrumentation applied to monitor cell cultures and describes the application of instrumentation to process control.

Original languageEnglish (US)
Title of host publicationCell Culture Technology for Pharmaceutical and Cell-Based Therapies
PublisherCRC Press
Pages249-297
Number of pages49
ISBN (Electronic)9780849351068
ISBN (Print)9780824753344
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine

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