@article{3d127ecb402247fdb46b8253f4180416,
title = "Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma",
abstract = "We have produced transgenic mouse strains harboring class II major histocompatibility complex or interferon-gamma genes linked to the human insulin promoter. These experiments were designed to investigate the consequences of the expression of immunological effector molecules by nonimmunological cells. In both of these studies we observed the disappearance from the pancreas of the insulin-producing β cells coinciding with the development of insulin-dependent diabetes mellitus. Transgenic mice expressing both chains of the I-A gene showed progressive atrophy of the islets of Langerhans, whereas mice expressing interferon-gamma suffered an inflammatory destruction of the islets.",
author = "Nora Sarvetnick and Denny Liggitt and Pitts, {Sharon L.} and Hansen, {Stanley E.} and Stewart, {Timothy A.}",
note = "Funding Information: N. S is supported by a postdoctoral fellowship from the Muscular Dystrophy Association. We wish to thank Laura Martin for animal care assistance and Carol Morita for graphics. We are extremely grateful for expert technical assistance of Philip Hollingshead. We thank Drs. Ed Choi, Hugh McDevitt, Axel Ullrich, and Pat Gray for the DNA clones used in this study and Drs. Robertson Parkman and Maxwell Cooper for the monoclonal antibody reactive with IA antigens. We would also like to thank Drs. Kevin Lafferty, Douglas Hanahan, and Howard Fox for helpful discussion. N. S. thanks Dr. Howard Fox for invaluable contributions during this work.",
year = "1988",
month = mar,
day = "11",
doi = "10.1016/0092-8674(88)90414-X",
language = "English (US)",
volume = "52",
pages = "773--782",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}