Insulin sensitizer combination therapy for type 2 diabetes

C. Desouza, V. A. Fonseca

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


To determine whether combination therapy with metformin and a thiazolidinedione was effective treatment for patients with type 2 diabetes mellitus whose primary pathology was insulin resistance, we studied 348 patients for 26 weeks. A combination of metformin and rosiglitazone lowered fasting plasma glucose levels by 52.9 mg/dL and increased the patients' ability to achieve a target glycosylated hemoglobin level of below 7%. Using a combination of metformin and a thiazolidinedione to treat, rather than compensate for, insulin resistance introduces the possibility of addressing issues beyond glycemic control, including cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalCardiology Review
Issue number1
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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