Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Ekaterina Chigrinova, Michael Mian, Yulei Shen, Timothy C. Greiner, Wing C. Chan, Julie M. Vose, Giorgio Inghirami, Annalisa Chiappella, Luca Baldini, Maurilio Ponzoni, Andrés J.M. Ferreri, Silvia Franceschetti, Gianluca Gaidano, Alessandra Tucci, Fabio Facchetti, Thierry Lazure, Olivier Lambotte, Santiago Montes-Moreno, Miguel A. Piris, Emanuele ZuccaIvo Kwee, Francesco Bertoni

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalBritish Journal of Haematology
Volume153
Issue number4
DOIs
StatePublished - May 2011

Keywords

  • Affymetrix
  • Aggressive lymphoma
  • Bone marrow
  • Gain
  • MiRNA

ASJC Scopus subject areas

  • Hematology

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