Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Ekaterina Chigrinova; Michael Mian; Yulei Shen; Timothy C. Greiner; Wing C. Chan; Julie M. Vose; Giorgio Inghirami; Annalisa Chiappella; Luca Baldini; Maurilio Ponzoni; Andrés J.M. Ferreri; Silvia Franceschetti; Gianluca Gaidano; Alessandra Tucci; Fabio Facchetti; Thierry Lazure; Olivier Lambotte; Santiago Montes-Moreno; Miguel A. Piris; Emanuele Zucca; Ivo Kwee; Francesco Bertoni

doi:10.1111/j.1365-2141.2011.08628.x

Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Ekaterina Chigrinova, Michael Mian, Yulei Shen, Timothy C. Greiner, Wing C. Chan, Julie M. Vose, Giorgio Inghirami, Annalisa Chiappella, Luca Baldini, Maurilio Ponzoni, Andrés J.M. Ferreri, Silvia Franceschetti, Gianluca Gaidano, Alessandra Tucci, Fabio Facchetti, Thierry Lazure, Olivier Lambotte, Santiago Montes-Moreno, Miguel A. Piris, Emanuele ZuccaIvo Kwee, Francesco Bertoni

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13 Scopus citations

Abstract

To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

Original language	English (US)
Pages (from-to)	499-503
Number of pages	5
Journal	British Journal of Haematology
Volume	153
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2011.08628.x
State	Published - May 2011

Keywords

Affymetrix
Aggressive lymphoma
Bone marrow
Gain
MiRNA

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2011.08628.x

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Chigrinova, E., Mian, M., Shen, Y., Greiner, T. C., Chan, W. C., Vose, J. M., Inghirami, G., Chiappella, A., Baldini, L., Ponzoni, M., Ferreri, A. J. M., Franceschetti, S., Gaidano, G., Tucci, A., Facchetti, F., Lazure, T., Lambotte, O., Montes-Moreno, S., Piris, M. A., ... Bertoni, F. (2011). Integrated profiling of diffuse large B-cell lymphoma with 7q gain. British Journal of Haematology, 153(4), 499-503. https://doi.org/10.1111/j.1365-2141.2011.08628.x

Chigrinova, E, Mian, M, Shen, Y, Greiner, TC, Chan, WC, Vose, JM, Inghirami, G, Chiappella, A, Baldini, L, Ponzoni, M, Ferreri, AJM, Franceschetti, S, Gaidano, G, Tucci, A, Facchetti, F, Lazure, T, Lambotte, O, Montes-Moreno, S, Piris, MA, Zucca, E, Kwee, I & Bertoni, F 2011, 'Integrated profiling of diffuse large B-cell lymphoma with 7q gain', British Journal of Haematology, vol. 153, no. 4, pp. 499-503. https://doi.org/10.1111/j.1365-2141.2011.08628.x

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AU - Mian, Michael

AU - Shen, Yulei

AU - Greiner, Timothy C.

AU - Chan, Wing C.

AU - Vose, Julie M.

AU - Inghirami, Giorgio

AU - Chiappella, Annalisa

AU - Baldini, Luca

AU - Ponzoni, Maurilio

AU - Ferreri, Andrés J.M.

AU - Franceschetti, Silvia

AU - Gaidano, Gianluca

AU - Tucci, Alessandra

AU - Facchetti, Fabio

AU - Lazure, Thierry

AU - Lambotte, Olivier

AU - Montes-Moreno, Santiago

AU - Piris, Miguel A.

AU - Zucca, Emanuele

AU - Kwee, Ivo

AU - Bertoni, Francesco

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KW - Affymetrix

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KW - Bone marrow

KW - Gain

KW - MiRNA

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Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Abstract

Keywords

ASJC Scopus subject areas

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