Interaction between the candida albicans high-osmolarity glycerol (HOG) pathway and the response to human β-defensins 2 and 3

Silvia Argimón, Saranna Fanning, Jill R. Blankenship, Aaron P. Mitchell

Research output: Contribution to journalComment/debate

28 Scopus citations

Abstract

Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.

Original languageEnglish (US)
Pages (from-to)272-275
Number of pages4
JournalEukaryotic Cell
Volume10
Issue number2
DOIs
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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