Interaction Of α-actinin, filamin and tropomyosin with F-actin

Michael G. Zeece; Richard M. Robson; Peter J. Bechtel

doi:10.1016/0005-2795(79)90258-7

Interaction Of α-actinin, filamin and tropomyosin with F-actin

Michael G. Zeece, Richard M. Robson, Peter J. Bechtel

Food Science and Technology

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The abilities of α-actinin, filamin and tropomyosin to bind F-actin were examined by cosedimentation experiments. Results indicated that smooth muscle α-actinin and filamin can bind to actin filaments simultaneously with little evidence of competition. In contrast, tropomyosin exhibits marked competition with either filamin or α-actinin for sites on actin filaments.

Original language	English (US)
Pages (from-to)	365-370
Number of pages	6
Journal	BBA - Protein Structure
Volume	581
Issue number	2
DOIs	https://doi.org/10.1016/0005-2795(79)90258-7
State	Published - Dec 14 1979

Keywords

Cell motility
F-Actin
Filamin
Myofibrillar protein
Tropomyosin
α-Actinin

ASJC Scopus subject areas

Medicine(all)

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10.1016/0005-2795(79)90258-7

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abstract = "The abilities of α-actinin, filamin and tropomyosin to bind F-actin were examined by cosedimentation experiments. Results indicated that smooth muscle α-actinin and filamin can bind to actin filaments simultaneously with little evidence of competition. In contrast, tropomyosin exhibits marked competition with either filamin or α-actinin for sites on actin filaments.",

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AU - Zeece, Michael G.

AU - Robson, Richard M.

AU - Bechtel, Peter J.

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AB - The abilities of α-actinin, filamin and tropomyosin to bind F-actin were examined by cosedimentation experiments. Results indicated that smooth muscle α-actinin and filamin can bind to actin filaments simultaneously with little evidence of competition. In contrast, tropomyosin exhibits marked competition with either filamin or α-actinin for sites on actin filaments.

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KW - F-Actin

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KW - Myofibrillar protein

KW - Tropomyosin

KW - α-Actinin

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