Interaction Of α-actinin, filamin and tropomyosin with F-actin

Michael G. Zeece, Richard M. Robson, Peter J. Bechtel

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The abilities of α-actinin, filamin and tropomyosin to bind F-actin were examined by cosedimentation experiments. Results indicated that smooth muscle α-actinin and filamin can bind to actin filaments simultaneously with little evidence of competition. In contrast, tropomyosin exhibits marked competition with either filamin or α-actinin for sites on actin filaments.

Original languageEnglish (US)
Pages (from-to)365-370
Number of pages6
JournalBBA - Protein Structure
Volume581
Issue number2
DOIs
StatePublished - Dec 14 1979

Keywords

  • Cell motility
  • F-Actin
  • Filamin
  • Myofibrillar protein
  • Tropomyosin
  • α-Actinin

ASJC Scopus subject areas

  • Medicine(all)

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