Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women

Hsing Wu Chen, Wen Hung Kuo, Yen Shen Lu, I. Chun Chen, Fu Chang Hu, Ming Yang Wang, Muhammad Zahid, Eleanor G. Rogan, Ann Lii Cheng, Ching Hung Lin

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: In East Asia, the incidence of breast cancer has been increasing rapidly, particularly among premenopausal women. An elevated ratio of estrogen-DNA adducts was linked to a higher risk of breast cancer. The present study explored the influence of the interaction between base excision repair (BER) gene polymorphisms and estrogen-DNA adducts on breast cancer risk. Methods: We conducted a case–control study comprising healthy volunteers and individuals with benign breast disease (control arm, n = 176) and patients with invasive carcinoma or carcinoma in situ (case arm, n = 177). Genotyping for BER-related genes, including SMUG1, OGG1, ERCC5, and APEX1, was performed. A logistic regression model, incorporating interactions between gene polymorphisms, estrogen-DNA adduct ratio, and clinical variables, was used to identify the risk factors for breast cancer. Results: Univariate analysis indicated marginal associations between breast cancer risk and APEX1 rs1130409 T > G (P = 0.057) and APEX1 rs1760944 T > G (P = 0.065). Multivariate regression analysis revealed significant associations with increased breast cancer risk for APEX1_rs1130409 (GT/GG versus TT) combined with a natural logarithmic value of the estrogen-DNA adduct ratio (estimated OR 1.164, P = 0.023) and premenopausal status with an estrogen-DNA adduct ratio > 2.93 (estimated OR 2.433, P = 0.001). Conclusion: APEX1_rs1130409 (GT/GG versus TT) polymorphisms, which are related to decreased BER activity, combined with an increased ratio of estrogen-DNA adducts, increase the risk of breast cancer in East Asian women.

Original languageEnglish (US)
Pages (from-to)283-292
Number of pages10
JournalBreast Cancer Research and Treatment
Volume208
Issue number2
DOIs
StatePublished - Nov 2024

Keywords

  • Base excision repair
  • Breast cancer
  • DNA adducts
  • Estrogen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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