Interactions of the human immunodeficiency virus with astrocytes

Avindra Nath, Christopher Power, Jonathan D. Geiger

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) can cause a dementing illness. Astrocytes, the most numerous cells within the central nervous system, can be infected with HIV-1. These cells are infected by predominantly lymphotropic strains of HIV-1. The mode of infection does not involve CD4 or galactocerebroside C and is, most likely, due to a unique binding-site protein located on the surface of astrocytes. The virus produces low levels of infection. Astrocytic function is significantly altered by viral proteins and nonviral products released by other infected cells. Future therapeutic developments for treating HIV-1 infection will need to take into account the unique mechanisms of interaction of HIV-1 with astrocytes. This review discusses astrocyte involvement in the pathogenesis of the HIV-1 cognitive motor complex.

Original languageEnglish (US)
Pages (from-to)30-42
Number of pages13
JournalPerspectives in Drug Discovery and Design
Volume5
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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