Interferon alfa-2a therapy for airway hemangiomas

Laurie A. Ohlms, Trevor J.I. McGill, Dwight T. Jones, Gerald B. Healy

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Hemangioma is a well-recognized cause of airway obstruction in the infant with stridor. Corticosteroid and laser therapy are effective in stabilizing the airway in most cases. There are, however, some extensive airway lesions that are not adequately managed by these modalities. This report describes the use of recombinant interferon alfa-2a in 15 patients with life-threatening airway hemangiomas. All patients had failed corticosteroid and/or laser therapy. Multiple upper airway sites were involved, including the base of the tongue, supraglottis, subglottis, trachea, and mediastinum. Eleven patients have completed therapy and are doing well. Four patients have resolving lesions on the drug regimen. Life-threatening airway lesions unresponsive to conventional treatment should be considered for a trial of interferon alfa-2a.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAnnals of Otology, Rhinology & Laryngology
Issue number1
StatePublished - Jan 1994
Externally publishedYes


  • hemangioma
  • interferon

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Interferon alfa-2a therapy for airway hemangiomas'. Together they form a unique fingerprint.

Cite this