Interferon alfa-2a therapy for airway hemangiomas

Laurie A. Ohlms, Trevor J.I. McGill, Dwight T. Jones, Gerald B. Healy

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Hemangioma is a well-recognized cause of airway obstruction in the infant with stridor. Corticosteroid and laser therapy are effective in stabilizing the airway in most cases. There are, however, some extensive airway lesions that are not adequately managed by these modalities. This report describes the use of recombinant interferon alfa-2a in 15 patients with life-threatening airway hemangiomas. All patients had failed corticosteroid and/or laser therapy. Multiple upper airway sites were involved, including the base of the tongue, supraglottis, subglottis, trachea, and mediastinum. Eleven patients have completed therapy and are doing well. Four patients have resolving lesions on the drug regimen. Life-threatening airway lesions unresponsive to conventional treatment should be considered for a trial of interferon alfa-2a.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalAnnals of Otology, Rhinology & Laryngology
Volume103
Issue number1
DOIs
StatePublished - Jan 1994

Keywords

  • hemangioma
  • interferon

ASJC Scopus subject areas

  • Otorhinolaryngology

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