TY - JOUR
T1 - Interferon regulatory factor 4 and 8 in B-cell development
AU - Lu, Runqing
N1 - Funding Information:
The author thanks Neena Haider for critical reading of the manuscript. R.L. is supported by National Institutes of Health Grant AI67891.
PY - 2008/10
Y1 - 2008/10
N2 - Interferon regulatory factor 4 (IRF4) and 8 are members of the interferon regulatory factor family of transcription factors and have been shown to be essential for the development and function of T cells, macrophages and dendritic cells. A series of recent studies have further demonstrated critical functions for IRF4 and 8 at several stages of B-cell development including pre-B-cell development, receptor editing, germinal center reaction and plasma cell generation. Collectively, these new studies provide molecular insights into the function of IRF4 and 8 and underscore a requirement for IRF4 and 8 throughout B-cell development. This review focuses on the recent advances on the roles of IRF4 and 8 in B-cell development.
AB - Interferon regulatory factor 4 (IRF4) and 8 are members of the interferon regulatory factor family of transcription factors and have been shown to be essential for the development and function of T cells, macrophages and dendritic cells. A series of recent studies have further demonstrated critical functions for IRF4 and 8 at several stages of B-cell development including pre-B-cell development, receptor editing, germinal center reaction and plasma cell generation. Collectively, these new studies provide molecular insights into the function of IRF4 and 8 and underscore a requirement for IRF4 and 8 throughout B-cell development. This review focuses on the recent advances on the roles of IRF4 and 8 in B-cell development.
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U2 - 10.1016/j.it.2008.07.006
DO - 10.1016/j.it.2008.07.006
M3 - Review article
C2 - 18775669
AN - SCOPUS:52049093870
SN - 1471-4906
VL - 29
SP - 487
EP - 492
JO - Trends in Immunology
JF - Trends in Immunology
IS - 10
ER -