Abstract
Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 445-453 |
| Number of pages | 9 |
| Journal | Seminars in Cancer Biology |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2001 |
Keywords
- EBV
- IRF-7
- LMP-1
- Latency
ASJC Scopus subject areas
- Cancer Research
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Zhang, L., & Pagano, J. S. (2001). Interferon regulatory factor 7: A key cellular mediator of LMP-1 in EBV latency and transformation. Seminars in Cancer Biology, 11(6), 445-453. https://doi.org/10.1006/scbi.2001.0411