Interferon regulatory factor 7: A key cellular mediator of LMP-1 in EBV latency and transformation

Luwen Zhang; Joseph S. Pagano

doi:10.1006/scbi.2001.0411

Interferon regulatory factor 7: A key cellular mediator of LMP-1 in EBV latency and transformation

Luwen Zhang, Joseph S. Pagano

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.

Original language	English (US)
Pages (from-to)	445-453
Number of pages	9
Journal	Seminars in Cancer Biology
Volume	11
Issue number	6
DOIs	https://doi.org/10.1006/scbi.2001.0411
State	Published - 2001
Externally published	Yes

Keywords

EBV
IRF-7
LMP-1
Latency

ASJC Scopus subject areas

Cancer Research

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10.1006/scbi.2001.0411

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title = "Interferon regulatory factor 7: A key cellular mediator of LMP-1 in EBV latency and transformation",

abstract = "Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.",

keywords = "EBV, IRF-7, LMP-1, Latency",

author = "Luwen Zhang and Pagano, {Joseph S.}",

note = "Funding Information: We thank Dr Shannon Kenney for critical reading of the manuscript. This work was supported in part by grants from the National Institute of Allergy and Infectious Diseases (AI 42372-01) and from the National Cancer Institute (CA 19014).",

year = "2001",

doi = "10.1006/scbi.2001.0411",

language = "English (US)",

volume = "11",

pages = "445--453",

journal = "Seminars in Cancer Biology",

issn = "1044-579X",

publisher = "Academic Press Inc.",

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T2 - A key cellular mediator of LMP-1 in EBV latency and transformation

AU - Zhang, Luwen

AU - Pagano, Joseph S.

N1 - Funding Information: We thank Dr Shannon Kenney for critical reading of the manuscript. This work was supported in part by grants from the National Institute of Allergy and Infectious Diseases (AI 42372-01) and from the National Cancer Institute (CA 19014).

PY - 2001

Y1 - 2001

N2 - Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.

AB - Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.

KW - EBV

KW - IRF-7

KW - LMP-1

KW - Latency

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Interferon regulatory factor 7: A key cellular mediator of LMP-1 in EBV latency and transformation

Abstract

Keywords

ASJC Scopus subject areas

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