Abstract
Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.
Original language | English (US) |
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Pages (from-to) | 445-453 |
Number of pages | 9 |
Journal | Seminars in Cancer Biology |
Volume | 11 |
Issue number | 6 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- EBV
- IRF-7
- LMP-1
- Latency
ASJC Scopus subject areas
- Cancer Research