Interferon regulatory factor 7: A key cellular mediator of LMP-1 in EBV latency and transformation

Luwen Zhang, Joseph S. Pagano

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein-Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and by activating IRF-7 protein through phosphorylation and nuclear translocation in a post-translational manner. The activated IRF-7 then functions to regulate both EBV and cellular target genes involved in latency, transformation and immune regulation. IRF-7 appears to be a key cellular latency protein involved in both the pathogenesis and persistence of EBV infection.

Original languageEnglish (US)
Pages (from-to)445-453
Number of pages9
JournalSeminars in Cancer Biology
Volume11
Issue number6
DOIs
StatePublished - 2001

Keywords

  • EBV
  • IRF-7
  • LMP-1
  • Latency

ASJC Scopus subject areas

  • Cancer Research

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