Intergeniculate leaflet ablation alters circadian rhythms in the mouse

Gary E. Pickard

doi:10.1097/00001756-199410270-00049

Intergeniculate leaflet ablation alters circadian rhythms in the mouse

Gary E. Pickard

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

The intergeniculate leaflet (IGL) receives retinal input and sends afferents to the hypothalamic suprachiasmatic nucleus (SCN), a circadian oscillator. The effect of IGL ablation on the circadian rhythm of wheel-running activity was examined in mice maintained in constant dark (DD) and in two intensities of constant light (LL). IGL-lesioned animals demonstrated significantly longer free-running rhythms in DD conditions than IGL-intact mice similarly housed; there was no effect of IGL ablation on the period of the free-running activity rhythm in LL of either 10 or 100 lux intensity. A change in the period of the free-running activity rhythm in DD following IGL destruction is evidence that the IGL exerts an endogenous influence on the SCN circadian system.’s disease.

Original language	English (US)
Pages (from-to)	2186-2188
Number of pages	3
Journal	NeuroReport
Volume	5
Issue number	16
DOIs	https://doi.org/10.1097/00001756-199410270-00049
State	Published - Oct 1994
Externally published	Yes

Keywords

Circadian rhythm
Intergeniculate leaflet
Mouse
Suprachiasmatic nucleus
Wheel-running activity

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1097/00001756-199410270-00049

Cite this

@article{2aa5e9c0278045f69c5aca368e2d29d7,

title = "Intergeniculate leaflet ablation alters circadian rhythms in the mouse",

abstract = "The intergeniculate leaflet (IGL) receives retinal input and sends afferents to the hypothalamic suprachiasmatic nucleus (SCN), a circadian oscillator. The effect of IGL ablation on the circadian rhythm of wheel-running activity was examined in mice maintained in constant dark (DD) and in two intensities of constant light (LL). IGL-lesioned animals demonstrated significantly longer free-running rhythms in DD conditions than IGL-intact mice similarly housed; there was no effect of IGL ablation on the period of the free-running activity rhythm in LL of either 10 or 100 lux intensity. A change in the period of the free-running activity rhythm in DD following IGL destruction is evidence that the IGL exerts an endogenous influence on the SCN circadian system.{\textquoteright}s disease.",

keywords = "Circadian rhythm, Intergeniculate leaflet, Mouse, Suprachiasmatic nucleus, Wheel-running activity",

author = "Pickard, {Gary E.}",

year = "1994",

month = oct,

doi = "10.1097/00001756-199410270-00049",

language = "English (US)",

volume = "5",

pages = "2186--2188",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "16",

}

TY - JOUR

T1 - Intergeniculate leaflet ablation alters circadian rhythms in the mouse

AU - Pickard, Gary E.

PY - 1994/10

Y1 - 1994/10

N2 - The intergeniculate leaflet (IGL) receives retinal input and sends afferents to the hypothalamic suprachiasmatic nucleus (SCN), a circadian oscillator. The effect of IGL ablation on the circadian rhythm of wheel-running activity was examined in mice maintained in constant dark (DD) and in two intensities of constant light (LL). IGL-lesioned animals demonstrated significantly longer free-running rhythms in DD conditions than IGL-intact mice similarly housed; there was no effect of IGL ablation on the period of the free-running activity rhythm in LL of either 10 or 100 lux intensity. A change in the period of the free-running activity rhythm in DD following IGL destruction is evidence that the IGL exerts an endogenous influence on the SCN circadian system.’s disease.

AB - The intergeniculate leaflet (IGL) receives retinal input and sends afferents to the hypothalamic suprachiasmatic nucleus (SCN), a circadian oscillator. The effect of IGL ablation on the circadian rhythm of wheel-running activity was examined in mice maintained in constant dark (DD) and in two intensities of constant light (LL). IGL-lesioned animals demonstrated significantly longer free-running rhythms in DD conditions than IGL-intact mice similarly housed; there was no effect of IGL ablation on the period of the free-running activity rhythm in LL of either 10 or 100 lux intensity. A change in the period of the free-running activity rhythm in DD following IGL destruction is evidence that the IGL exerts an endogenous influence on the SCN circadian system.’s disease.

KW - Circadian rhythm

KW - Intergeniculate leaflet

KW - Mouse

KW - Suprachiasmatic nucleus

KW - Wheel-running activity

UR - http://www.scopus.com/inward/record.url?scp=0028110320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028110320&partnerID=8YFLogxK

U2 - 10.1097/00001756-199410270-00049

DO - 10.1097/00001756-199410270-00049

M3 - Article

C2 - 7865773

AN - SCOPUS:0028110320

SN - 0959-4965

VL - 5

SP - 2186

EP - 2188

JO - NeuroReport

JF - NeuroReport

IS - 16

ER -

Intergeniculate leaflet ablation alters circadian rhythms in the mouse

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this