Intergeniculate leaflet ablation alters circadian rhythms in the mouse

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45 Scopus citations

Abstract

The intergeniculate leaflet (IGL) receives retinal input and sends afferents to the hypothalamic suprachiasmatic nucleus (SCN), a circadian oscillator. The effect of IGL ablation on the circadian rhythm of wheel-running activity was examined in mice maintained in constant dark (DD) and in two intensities of constant light (LL). IGL-lesioned animals demonstrated significantly longer free-running rhythms in DD conditions than IGL-intact mice similarly housed; there was no effect of IGL ablation on the period of the free-running activity rhythm in LL of either 10 or 100 lux intensity. A change in the period of the free-running activity rhythm in DD following IGL destruction is evidence that the IGL exerts an endogenous influence on the SCN circadian system.’s disease.

Original languageEnglish (US)
Pages (from-to)2186-2188
Number of pages3
JournalNeuroReport
Volume5
Issue number16
DOIs
StatePublished - Oct 1994

Keywords

  • Circadian rhythm
  • Intergeniculate leaflet
  • Mouse
  • Suprachiasmatic nucleus
  • Wheel-running activity

ASJC Scopus subject areas

  • Neuroscience(all)

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