TY - JOUR
T1 - Interleukin 1 - A possible mediator of neural fibrosis in leprosy
AU - Band, Hamid
N1 - Funding Information:
Hamid Band, Division of Immunogenetics, Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02 115. ( Supported by NIH Grant CA 2053 I to Dr. Edmond J. Yunis 1.
PY - 1986/6
Y1 - 1986/6
N2 - Neural fibrosis in leprosy, the disease caused by the obligate intracellular bacterium, Mycobacterium leprae, is closely related to the cell-mediated immune response to this microorganism. The fibrosis appears to be due to soluble mediators released by the immune effector cells. Interleukin 1, a macrophage product that stimulates fibroblast migration, proliferation and synthetic activity, possesses the requisite properties to qualify for such a mediator.
AB - Neural fibrosis in leprosy, the disease caused by the obligate intracellular bacterium, Mycobacterium leprae, is closely related to the cell-mediated immune response to this microorganism. The fibrosis appears to be due to soluble mediators released by the immune effector cells. Interleukin 1, a macrophage product that stimulates fibroblast migration, proliferation and synthetic activity, possesses the requisite properties to qualify for such a mediator.
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U2 - 10.1016/0306-9877(86)90120-9
DO - 10.1016/0306-9877(86)90120-9
M3 - Article
C2 - 3488493
AN - SCOPUS:0022519942
SN - 0306-9877
VL - 20
SP - 143
EP - 150
JO - Medical Hypotheses
JF - Medical Hypotheses
IS - 2
ER -