TY - JOUR
T1 - Interleukin 13 and its role in gut defence and inflammation
AU - Mannon, Peter Mannon
AU - Reinisch, Walter Reinisch
PY - 2013/8
Y1 - 2013/8
N2 - Interleukin 13 (IL-13) is a cytokine of increasing interest to gastroenterologists because of its developing role in ulcerative colitis, eosinophilic esophagitis (EO) and fibrosis. Recent data show that IL-13 may play an important role in a novel innate immune response since it can be released by signals from an injured or inflamed epithelium, of particular relevance to the gut. Animal models of IL-13-driven inflammation (from asthma to colitis and EO) are being translated to human disease and providing insight into potential strategies for new therapies. In fact, multiple clinical trials using anti-IL-13 drugs are underway in asthma and are being extended to gastrointestinal diseases. This review presents the current knowledge on IL-13 production and function in the gut, including the cells and receptor signalling pathways involved in mediating IL-13 effects, the proposed mechanisms of IL-13 induced gut disease and the many drugs currently being tested that target IL-13 related pathways.
AB - Interleukin 13 (IL-13) is a cytokine of increasing interest to gastroenterologists because of its developing role in ulcerative colitis, eosinophilic esophagitis (EO) and fibrosis. Recent data show that IL-13 may play an important role in a novel innate immune response since it can be released by signals from an injured or inflamed epithelium, of particular relevance to the gut. Animal models of IL-13-driven inflammation (from asthma to colitis and EO) are being translated to human disease and providing insight into potential strategies for new therapies. In fact, multiple clinical trials using anti-IL-13 drugs are underway in asthma and are being extended to gastrointestinal diseases. This review presents the current knowledge on IL-13 production and function in the gut, including the cells and receptor signalling pathways involved in mediating IL-13 effects, the proposed mechanisms of IL-13 induced gut disease and the many drugs currently being tested that target IL-13 related pathways.
UR - http://www.scopus.com/inward/record.url?scp=84880346076&partnerID=8YFLogxK
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U2 - 10.1136/postgradmedj-2012-303461rep
DO - 10.1136/postgradmedj-2012-303461rep
M3 - Article
C2 - 23861499
AN - SCOPUS:84880346076
VL - 89
SP - 448
EP - 456
JO - Postgraduate Medical Journal
JF - Postgraduate Medical Journal
SN - 0032-5473
IS - 1054
ER -