Abstract
Interleukin 8 (IL-8) is a chemotactic factor that attracts neutrophils, basophils, and T-cells during the inflammatory process. It is not a chemotactic factor for monocytes. IL-8 is involved in neutrophil activation, and is released from several cell types in response to inflammation, including monocytes, macrophages, neutrophils, and intestine, kidney, placenta, and bone marrow cells. It is a member of the beta-thromboglobulin superfamily and is structurally related to platelet factor 4. IL-8 is involved in mitogenesis, inhibition of angiogenesis, inflammation, chemotaxis, neutrophil degranulation, leukocyte activation, and calcium homeostasis. © 2007
| Original language | English (US) |
|---|---|
| Title of host publication | xPharm |
| Subtitle of host publication | The Comprehensive Pharmacology Reference |
| Publisher | Elsevier Inc. |
| Pages | 1-4 |
| Number of pages | 4 |
| ISBN (Print) | 9780080552323 |
| DOIs | |
| State | Published - 2007 |
ASJC Scopus subject areas
- General Pharmacology, Toxicology and Pharmaceutics