Interleukin 8

Kathleen Brennan, Jialin Zheng

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


Interleukin 8 (IL-8) is a chemotactic factor that attracts neutrophils, basophils, and T-cells during the inflammatory process. It is not a chemotactic factor for monocytes. IL-8 is involved in neutrophil activation, and is released from several cell types in response to inflammation, including monocytes, macrophages, neutrophils, and intestine, kidney, placenta, and bone marrow cells. It is a member of the beta-thromboglobulin superfamily and is structurally related to platelet factor 4. IL-8 is involved in mitogenesis, inhibition of angiogenesis, inflammation, chemotaxis, neutrophil degranulation, leukocyte activation, and calcium homeostasis. © 2007

Original languageEnglish (US)
Title of host publicationxPharm
Subtitle of host publicationThe Comprehensive Pharmacology Reference
PublisherElsevier Inc.
Number of pages4
ISBN (Print)9780080552323
StatePublished - 2007

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)


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