Interoceptive Stimulus Effects of Drugs of Abuse

Brady M. Thompson, Rick A. Bevins, Jennifer E. Murray

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


There has been an increasing interest in the role of interoception in drug addiction. Work in this area has largely come from two different directions. The first direction being from altered neural activity in individuals with substance use disorders that impairs emotional processing. Thus, physiological changes caused by drugs or drug-associated stimuli are interpreted in ways that evoke drug cravings, thereby driving enhanced drug seeking. The second direction being from the study of operant and Pavlovian conditioning processes. Here, drug effects are conceptualized as interoceptive stimuli that acquire control over behavior. Such learned alterations involving drug stimuli come to guide drug-related behaviors that affect risk and abuse liability. This chapter delves into the point at which these approaches appear to be converging, and discusses where we are in our understanding today and how this research may inform improved therapeutic techniques.

Original languageEnglish (US)
Title of host publicationNeural Mechanisms of Addiction
Number of pages13
ISBN (Electronic)9780128122020
ISBN (Print)9780128123317
StatePublished - Jan 1 2018


  • Alcohol
  • Associative learning
  • Cue competition
  • Cue-exposure therapy
  • Drug discrimination
  • Extinction
  • Insula
  • Nicotine
  • Operant conditioning
  • Pavlovian conditioning
  • Relapse
  • Striatum

ASJC Scopus subject areas

  • General Medicine
  • General Neuroscience


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