Interplay of distinct growth factors during epithelial-mesenchymal transition of cancer progenitor cells and molecular targeting as novel cancer therapies

M. Mimeault, S. K. Batra

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations

Abstract

In this review, we describe the critical functions assumed by the interplay of epidermal growth factor, hedgehog, Wnt/β-catenin, tumor growth factor-β and integrin signaling cascades in tumorigenic and migrating cancer progenitor cells and activated stromal cells during carcinogenesis. These growth factors provide an important role for the sustained growth and survival of tumorigenic cancer progenitor cells and their progeny by up-regulating numerous mitotic and antiapoptotic signaling cascades. Furthermore, these potent morphogens may cooperate for inducing the molecular events associated with the epithelial-mesenchymal program in cancer cells including the alterations in epithelial cell shape and motility through the dissociation of intercellular adherens junctions. Of therapeutic interest, new strategies for the development of more effective clinical treatments against the locally aggressive and invasive cancers based on the molecular targeting of deregulated signaling elements in tumorigenic and migrating cancer cells and their local microenvironment are also described.

Original languageEnglish (US)
Pages (from-to)1605-1619
Number of pages15
JournalAnnals of Oncology
Volume18
Issue number10
DOIs
StatePublished - Oct 2007

Keywords

  • Cancer progenitor cells
  • Epithelial-mesenchymal transition
  • Invasion
  • Metastasis
  • Stromal micro environment
  • Targeting therapies

ASJC Scopus subject areas

  • Hematology
  • Oncology

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