Intestinal abnormalities with central nervous system malignancy

Stuart S. Kaufman, Constance M. Goldgar, Francis Fitzmaurice, Dean L. Antonson, Jon A. Vanderhoof

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Two anorectic, emaciated infants with central nervous system (CNS) neoplasms are reported. Diagnosis in each case was delayed, because computed tomography of the head was initially falsely negative, and because primary gastroenterologic illness was suggested by the presence of mild inflammation and villous atrophy of the small intestine. This experience indicates that the diagnosis of CNS neoplasm must be aggressively pursued in cachectic infants who refuse to eat, regardless of the results of the initial radiologic studies. Mild histologic abnormalities of the small intestine that may be present in infants with brain tumors probably represent a nonspecific response to starvationand, if unassociated with malabsorption, should not be considered the cause of illness.

Original languageEnglish (US)
Pages (from-to)665-670
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Issue number4
StatePublished - 1986
Externally publishedYes


  • Brain tumors
  • Central nervous system
  • Infants
  • Intestine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology


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