Intestinal failure-associated liver disease: Causes, manifestations and therapies

Fedja A. Rochling, Hilary A. Catron

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Purpose of reviewThe goal of this review is to provide updates on the causes, manifestations and therapies IFALD in adults with an emphasis on recent discoveries on pathways of pathogenesis and interventions to reduce the incidence of IFALD.Recent findingsIFALD is a multifactorial complication of long-term home parenteral therapy. Although exact pathways are unknown, altered bile acid metabolism, microbiome dysbiosis impact on the gut-liver axis and soybean-based lipid formulations are major drivers of IFALD development.SummaryIFALD contributes to morbidity and mortality in patients on parenteral nutrition. Proactive management by a multidisciplinary team has led to improved outcomes in at-risk patients. Attention to early treatment and prevention of sepsis, introduction of nonsoybean based lipid formulations, surgical procedures such as step enteroplasties and, potentially, microbiome dysbiosis are considerations in IFLAD management.

Original languageEnglish (US)
Pages (from-to)126-133
Number of pages8
JournalCurrent opinion in gastroenterology
Volume35
Issue number2
DOIs
StatePublished - Mar 1 2019

Keywords

  • intestinal failure-associated liver disease
  • microbiome
  • parenteral nutrition
  • short bowel syndrome

ASJC Scopus subject areas

  • Gastroenterology

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