TY - JOUR
T1 - Intestinal failure-associated liver disease
T2 - Causes, manifestations and therapies
AU - Rochling, Fedja A.
AU - Catron, Hilary A.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Purpose of reviewThe goal of this review is to provide updates on the causes, manifestations and therapies IFALD in adults with an emphasis on recent discoveries on pathways of pathogenesis and interventions to reduce the incidence of IFALD.Recent findingsIFALD is a multifactorial complication of long-term home parenteral therapy. Although exact pathways are unknown, altered bile acid metabolism, microbiome dysbiosis impact on the gut-liver axis and soybean-based lipid formulations are major drivers of IFALD development.SummaryIFALD contributes to morbidity and mortality in patients on parenteral nutrition. Proactive management by a multidisciplinary team has led to improved outcomes in at-risk patients. Attention to early treatment and prevention of sepsis, introduction of nonsoybean based lipid formulations, surgical procedures such as step enteroplasties and, potentially, microbiome dysbiosis are considerations in IFLAD management.
AB - Purpose of reviewThe goal of this review is to provide updates on the causes, manifestations and therapies IFALD in adults with an emphasis on recent discoveries on pathways of pathogenesis and interventions to reduce the incidence of IFALD.Recent findingsIFALD is a multifactorial complication of long-term home parenteral therapy. Although exact pathways are unknown, altered bile acid metabolism, microbiome dysbiosis impact on the gut-liver axis and soybean-based lipid formulations are major drivers of IFALD development.SummaryIFALD contributes to morbidity and mortality in patients on parenteral nutrition. Proactive management by a multidisciplinary team has led to improved outcomes in at-risk patients. Attention to early treatment and prevention of sepsis, introduction of nonsoybean based lipid formulations, surgical procedures such as step enteroplasties and, potentially, microbiome dysbiosis are considerations in IFLAD management.
KW - intestinal failure-associated liver disease
KW - microbiome
KW - parenteral nutrition
KW - short bowel syndrome
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U2 - 10.1097/MOG.0000000000000503
DO - 10.1097/MOG.0000000000000503
M3 - Review article
C2 - 30585838
AN - SCOPUS:85060629831
VL - 35
SP - 126
EP - 133
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
SN - 0267-1379
IS - 2
ER -