Intestinal neoplasia in the Apc(Min) mouse: Independence from the microbial and natural killer (beige locus) status

William F. Dove, Linda Clipson, Karen A. Gould, Cindy Luongo, David J. Marshall, Amy R. Moser, Michael A. Newton, Russell F. Jacoby

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

We have tested the hypothesis that enteric bacteria are necessary for formation of intestinal adenomas in C57BL/6-Apc(Min)/+ mouse. Germ-free mice developed 2-fold fewer adenomas than conventional controls in the medial small intestine (7.3 versus 14.9; P < 0.003), but there were no significant differences in the rest of the intestinal tract. We conclude that microbial status does not strongly alter the adenoma phenotype in this mouse model of familial adenomatous polyposis. In parallel, we have found that C57BL/6- Apc(MIN)/+ mice mutated at the beige locus, which controls natural killer activity, are also unaltered in adenoma multiplicity.

Original languageEnglish (US)
Pages (from-to)812-814
Number of pages3
JournalCancer Research
Volume57
Issue number5
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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