Into the linker's DENN: A tyrosine's control of autophagy

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


The small GTP-binding protein Rab12 plays an important role in the initiation of starvation-induced macroautophagy (autophagy) and is activated by the guanine-nucleotide exchange factor DENND3. However, the molecular mechanism by which DENND3 becomes activated has remained elusive. Xu and McPherson now identify a novel mechanism of DENND3 intramolecular binding that is regulated by the phosphorylation of a single tyrosine residue.

Original languageEnglish (US)
Pages (from-to)7283-7284
Number of pages2
JournalJournal of Biological Chemistry
Issue number17
StatePublished - Apr 28 2017

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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