Intracellular cesium separates two glutamate conductances in retinal bipolar cells of goldfish

Scott Nawy, David R. Copenhagen

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The responses of depolarizing bipolar cells to glutamate were investigated in the superfused isolated goldfish retina. In intracellular recordings with potassium-filled microelectrodes, glutamate hyperpolarized cells but did not alter the net input conductance. In recordings with cesium-filled microelectrodes, the glutamate-evoked hyperpolarization was associated with a net conductance decrease. In the presence of internal cesium, glutamate action had the same reversal potential as the actions of the glutamate analog 2-amino-4-phosphonobutyrate (APB) and the rod transmitter, suggesting that all three of these substances act at the same class of receptor. We propose that glutamate acts both at the APB-sensitive receptor that mediates rod inputs and at another receptor type that produces a conductance increase, is blocked by cesium, and may mimic the action of the cone transmitter.

Original languageEnglish (US)
Pages (from-to)967-972
Number of pages6
JournalVision research
Volume30
Issue number7
DOIs
StatePublished - 1990

Keywords

  • Bipolar cell Retina Synaptic transmission Glutamate APB Goldfish Carassius auratus

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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