TY - JOUR
T1 - Intracrevicular application of tetracycline in white petrolatum for the treatment of periodontal disease
AU - Eckles, Terry A.
AU - Reinhardt, Richard A.
AU - Dyer, John K.
AU - Tussing, Gerald J.
AU - Szydlowski, Wieslaw M.
AU - DuBous, Lnda M.
PY - 1990/8
Y1 - 1990/8
N2 - Abstract. In vitro tests in our laboratory have shown that 40% tetracycline HC1 in a white petrolatum carrier (TTC‐WP) has potential as a sustained release, auto‐dissipating system. The present study tested subgingival placement of TTC‐WP via syringe in vivo. Quadrants (2 diseased sites in each) in 9 patients with moderate/severe periodontitis were randomly assigned to receive the following treatments: (1) TTC‐WP; (2) WP only; (3) scaling and root planing; (4) untreated control. TTC release into gingival crevicular fluid (GCF) over time (baseline, 1, 8, 24, 72 and 168 h) was measured using an agar diffusion bioassay. Clinical parameters and subgingival bacterial morphotypes (darkfield analysis) were also evaluated over time (baseline, 2, 4, 8, 12 weeks). Results indicated that TTC‐WP was easily placed into periodontal pockets and biologically effective TTC was released into GCF for at least 3 days (mean concentration = 115.8 ± 43.1 μg/ml at 3 days). TTC‐WP reduced probing pocket depths and bleeding on probing relative to baseline measurements for 8–12 weeks post‐treatment, and reduced %s of motile rods and spirochetes, with an accompanying increase in cocci, for 2–8 weeks. Similar effects were noted in the scaled and root‐planed sites, but for a longer duration. TTC‐WP and WP were clinically dissipated after 2 weeks and no adverse tissue reactions were observed. From these findings, subgingival TTC‐WP cannot replace scaling and root planing therapy, but has characteristics useful in subgingival plaque control.
AB - Abstract. In vitro tests in our laboratory have shown that 40% tetracycline HC1 in a white petrolatum carrier (TTC‐WP) has potential as a sustained release, auto‐dissipating system. The present study tested subgingival placement of TTC‐WP via syringe in vivo. Quadrants (2 diseased sites in each) in 9 patients with moderate/severe periodontitis were randomly assigned to receive the following treatments: (1) TTC‐WP; (2) WP only; (3) scaling and root planing; (4) untreated control. TTC release into gingival crevicular fluid (GCF) over time (baseline, 1, 8, 24, 72 and 168 h) was measured using an agar diffusion bioassay. Clinical parameters and subgingival bacterial morphotypes (darkfield analysis) were also evaluated over time (baseline, 2, 4, 8, 12 weeks). Results indicated that TTC‐WP was easily placed into periodontal pockets and biologically effective TTC was released into GCF for at least 3 days (mean concentration = 115.8 ± 43.1 μg/ml at 3 days). TTC‐WP reduced probing pocket depths and bleeding on probing relative to baseline measurements for 8–12 weeks post‐treatment, and reduced %s of motile rods and spirochetes, with an accompanying increase in cocci, for 2–8 weeks. Similar effects were noted in the scaled and root‐planed sites, but for a longer duration. TTC‐WP and WP were clinically dissipated after 2 weeks and no adverse tissue reactions were observed. From these findings, subgingival TTC‐WP cannot replace scaling and root planing therapy, but has characteristics useful in subgingival plaque control.
KW - periodontal treatment
KW - periodontitis
KW - subginoival medications
KW - tetracycline
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U2 - 10.1111/j.1600-051X.1990.tb02344.x
DO - 10.1111/j.1600-051X.1990.tb02344.x
M3 - Article
C2 - 2201706
AN - SCOPUS:0025314117
SN - 0303-6979
VL - 17
SP - 454
EP - 462
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 7
ER -