Intramolecular Hydrogen Atom Transfer in Aminyl Radical at Room Temperature with Large Kinetic Isotope Effect

Ying Wang; Arnon Olankitwanit; Suchada Rajca; Andrzej Rajca

doi:10.1021/jacs.7b02692

Intramolecular Hydrogen Atom Transfer in Aminyl Radical at Room Temperature with Large Kinetic Isotope Effect

Ying Wang, Arnon Olankitwanit, Suchada Rajca, Andrzej Rajca

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We report a large kinetic isotope effect at 298 K, k_H/k_D ≈ 150, associated with an intramolecular 1,5-hydrogen atom transfer (1,5-HAT) in the decay of a PEGylated carbazyl (aminyl) radical in solution. The experimental observations surprisingly combine the hallmarks of tunneling, including large KIEs and unusual activation parameters, with linear Arrhenius and Eyring plots over an exceptionally wide temperature range of 116 K.

Original language	English (US)
Pages (from-to)	7144-7147
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	139
Issue number	21
DOIs	https://doi.org/10.1021/jacs.7b02692
State	Published - May 31 2017

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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abstract = "We report a large kinetic isotope effect at 298 K, kH/kD ≈ 150, associated with an intramolecular 1,5-hydrogen atom transfer (1,5-HAT) in the decay of a PEGylated carbazyl (aminyl) radical in solution. The experimental observations surprisingly combine the hallmarks of tunneling, including large KIEs and unusual activation parameters, with linear Arrhenius and Eyring plots over an exceptionally wide temperature range of 116 K.",

author = "Ying Wang and Arnon Olankitwanit and Suchada Rajca and Andrzej Rajca",

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AU - Olankitwanit, Arnon

AU - Rajca, Suchada

AU - Rajca, Andrzej

PY - 2017/5/31

Y1 - 2017/5/31

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AB - We report a large kinetic isotope effect at 298 K, kH/kD ≈ 150, associated with an intramolecular 1,5-hydrogen atom transfer (1,5-HAT) in the decay of a PEGylated carbazyl (aminyl) radical in solution. The experimental observations surprisingly combine the hallmarks of tunneling, including large KIEs and unusual activation parameters, with linear Arrhenius and Eyring plots over an exceptionally wide temperature range of 116 K.

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