Intraoperative Margin Re-Resection for Colorectal Liver Metastases

Curtis J. Wray, Andrew M. Lowy, Jeffrey B. Matthews, Laura E. James, Joshua M. Mammen, Kyuran A. Choe, Douglas W. Hanto, Syed A. Ahmad

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: Evaluate recurrence and survival in patients who underwent intraoperative margin re-resection for colorectal cancer liver (CRC) metastases. Design: Retrospective analysis. Setting: University Hospital, Cincinnati, Ohio. Academic medical center. Participants: Cohort of 118 patients who underwent resection of CRC liver metastases between 1992 and 2004. All patients were divided into 3 groups: resection margin (MOR) less than 1 cm (n = 64), MOR greater than 1 cm (n = 33), and re-resection margin (re-MOR) greater than 1 cm (n = 21). Results: Patients with a margin greater than 1 cm, when compared with re-MOR greater than 1 had decreased incidence of liver and distant recurrence (p < 0.05) as well as improved disease-free survival (39.2 vs 22.9 months, p = 0.023). Differences in overall survival (58.6 vs 44.2 months, p = 0.14) were not significant. Conclusion: Intraoperative re-resection is associated with an increased risk of local and distant recurrence, which may be a reflection of both inadequate surgery and underlying tumor biology.

Original languageEnglish (US)
Pages (from-to)150-157
Number of pages8
JournalJournal of Surgical Education
Issue number3
StatePublished - May 2007
Externally publishedYes


  • colorectal cancery
  • hepatectomy
  • hepatic neoplasms
  • Medical Knowledge
  • metastasis

ASJC Scopus subject areas

  • Surgery
  • Education


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