Abstract
Objective: Evaluate recurrence and survival in patients who underwent intraoperative margin re-resection for colorectal cancer liver (CRC) metastases. Design: Retrospective analysis. Setting: University Hospital, Cincinnati, Ohio. Academic medical center. Participants: Cohort of 118 patients who underwent resection of CRC liver metastases between 1992 and 2004. All patients were divided into 3 groups: resection margin (MOR) less than 1 cm (n = 64), MOR greater than 1 cm (n = 33), and re-resection margin (re-MOR) greater than 1 cm (n = 21). Results: Patients with a margin greater than 1 cm, when compared with re-MOR greater than 1 had decreased incidence of liver and distant recurrence (p < 0.05) as well as improved disease-free survival (39.2 vs 22.9 months, p = 0.023). Differences in overall survival (58.6 vs 44.2 months, p = 0.14) were not significant. Conclusion: Intraoperative re-resection is associated with an increased risk of local and distant recurrence, which may be a reflection of both inadequate surgery and underlying tumor biology.
Original language | English (US) |
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Pages (from-to) | 150-157 |
Number of pages | 8 |
Journal | Journal of Surgical Education |
Volume | 64 |
Issue number | 3 |
DOIs | |
State | Published - May 2007 |
Externally published | Yes |
Keywords
- colorectal cancery
- hepatectomy
- hepatic neoplasms
- Medical Knowledge
- metastasis
ASJC Scopus subject areas
- Surgery
- Education