Intratumoral administration of 5-[123I]iodo-2′ deoxyuridine in a patient with a brain tumor

Amin I. Kassis, Sabah S. Tumeh, Patrick Y.C. Wen, Janina Baranowska-Kortylewicz, Annick D. Van Den Abbeele, Robert E. Zimmerman, Paulo A. Carvalho, Basem M. Garada, William C. DeSisto, Nancy Olsen Bailey, Frank P. Castronovo, Giuliano Mariani, Peter Mc L. Black, S. James Adelstein

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

We have initiated a study in which patients suspected of having primary gliomas are given a single intracerebral injection of the thymidine analog 5-[123I]iodo-2′-deoxyuridine ([123I]IUdR). The purpose of the study is to determine the biodistribution of the radiopharmaceutical and to calculate dose estimates to the tumor and normal tissues. Methods: A patient with a cystic glioma was injected with [123I]IUdR. Whole-body scans and brain scans were obtained at various times after injection, and blood, urine and stools were collected and assayed for radioactivity to assess its biodistribution and clearance. Results: Scintigraphic imaging demonstrated that the distribution of radiolabeled IUdR was mainly confined to the tumor (injection site), stomach and bladder. Disappearance from the tumor site and blood clearance were delayed probably due to collection in the cystic lesion. Eighty percent of the injected dose was recovered in the urine. Conclusion: The pharmacokinetics of [123I]IUdR locoregionally administered to a human glioma in situ resembled those observed in a rat glioma model where administration of the radiopharmaceutical radiolabeled with the Auger electron emitter 125I was therapeutically effective.

Original languageEnglish (US)
Pages (from-to)19S-22S
JournalJournal of Nuclear Medicine
Volume37
Issue number4 SUPPL.
StatePublished - Apr 1 1996

Keywords

  • Central nervous system tumors
  • Intratumoral injection
  • Iodine-123-IUdR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Kassis, A. I., Tumeh, S. S., Wen, P. Y. C., Baranowska-Kortylewicz, J., Van Den Abbeele, A. D., Zimmerman, R. E., Carvalho, P. A., Garada, B. M., DeSisto, W. C., Bailey, N. O., Castronovo, F. P., Mariani, G., Black, P. M. L., & Adelstein, S. J. (1996). Intratumoral administration of 5-[123I]iodo-2′ deoxyuridine in a patient with a brain tumor. Journal of Nuclear Medicine, 37(4 SUPPL.), 19S-22S.