Abstract
A study was conducted to compare the efficacy and safety of two methods of delivering prostaglandin E 2 (PGE 2) as a low-dose gel delivered in up to two sequential, 2.5-mg doses and as a single-dose, controlled-release, 10-mg pessary. A cervical change was present in both groups, but a Bishop score ≥8 occurred in more nulliparous patients in the pessary than in the gel group by 12 hours after dosing. Labor was initiated without oxytocin more frequently in the pessary than gel group for nulliparas and multiparas. Reversal of uterine hyperstimulation was possible by removal of the pessary without tocolytic therapy. The controlled-release PGE 2 pessary was more effective in changing the cervix in nulliparas and in initiating labor and offered the advantage of removal when desired.
Original language | English (US) |
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Pages (from-to) | 381-386 |
Number of pages | 6 |
Journal | Journal of Reproductive Medicine for the Obstetrician and Gynecologist |
Volume | 39 |
Issue number | 5 |
State | Published - 1994 |
Keywords
- cervix uteri
- dinoprostone
- labor, induced
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology