Intravascular Ultrasonic Imaging of Coronary Arterial Remodeling in Heart Transplant Recipients

Kosaku Goto, Ioannis Iakovou, Aggeliki Gkouziouta, Akiko Maehara, Gary S. Mintz, Georgios Karavolias, Vaggelis Leontiadis, Vasilis Voudris, Gregory Pavlides, Stamatios Adamopoulos

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The purpose of this study was to evaluate long-term changes of transplant coronary arteries, including vessel, plaque, and lumen areas. There are limited long-term data on vessel remodeling after heart transplantation. We analyzed serial intravascular ultrasound images of the left anterior descending coronary artery (LAD) in 54 heart transplantation recipients. Nine patients (16.7%) had a history of rejection. Proximal left anterior descending artery segments were matched among time points, a ≥20-mm long segment was analyzed every 1 mm, and results were normalized for analysis length and reported as mm3/mm. During follow-up, vessel area decreased (-0.48 ± 1.3 mm3/mm/year), and plaque area did not change (-0.01 ± 0.47 mm3/mm/year). As a result, lumen area decreased (-0.52 ± 1.34 mm3/mm/year). The change in mean lumen area was well correlated to the change in mean vessel area (r = 0.94, p <0.01) but not to the change in mean plaque area (r = -0.27, p = 0.05). In conclusion, lumen loss occurred during long-term follow-up of patients who underwent heart transplantation, primarily secondary to negative remodeling (decrease in vessel dimensions).

Original languageEnglish (US)
Pages (from-to)785-790
Number of pages6
JournalAmerican Journal of Cardiology
Issue number5
StatePublished - 2015
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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