Intravenous immunoglobulin in rheumatic disease

L. W. Klassen, L. H. Calabrese, R. M. Laxer

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


With the advent of numerous commerical perparations of intravenous immunoglobulin preparations since 1981, it is now possible to administer these preparations in significant quantities to cause elevation of serum immunoglobulin levels both in patients with antibody-deficient states and in those with normal circulating immunoglobulin levels. This led to a report of dramatic improvement of thrombocytopenia in a child with agammaglobulin following the use of intravenous immunoglobulin preparations for recurrent infections, and further studies in both children and adults with associated symptoms suggested therapeutic efficacy of intravenous immunoglobulin preparations in controlling autoimmune symptoms.

Original languageEnglish (US)
Pages (from-to)155-173
Number of pages19
JournalRheumatic Disease Clinics of North America
Issue number1
StatePublished - 1996

ASJC Scopus subject areas

  • Rheumatology


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