Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species

Peter C. Iwen, Stephanie D. Schutte, Diana F. Florescu, Rhonda K. Noel-Hurst, Lynne Sigler

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Scopulariopsis species and their Microascus teleomorphs are cosmopolitan fungi that are uncommonly associated with invasive disease. This report describes a case of fatal disseminated Scopulariopsis brevicaulis disease in a patient with diffuse large B cell lymphoma who underwent high-dose chemotherapy followed by a matched unrelated donor stem cell transplant. This case is compared with 32 prior cases of proven invasive Scopulariopsis (Microascus) infections reported in the literature. A focus of this report is the diagnostic methods utilized which included histopathology and culture with both micromorphologic and genotypic procedures employed to confirm the species identification.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalMedical Mycology
Volume50
Issue number6
DOIs
StatePublished - Aug 2012

Keywords

  • Genomic
  • Histopathology
  • Internal transcribed spacer region
  • Invasive mold
  • Microascus
  • Scopulariopsis brevicaulis

ASJC Scopus subject areas

  • Infectious Diseases

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