Investigating cortico-striatal pathophysiology in obsessive-compulsive disorders: Procedural learning and imaging probes

Scott L. Rauch, Cary R. Savage

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Obsessive-compulsive disorder (OCD) is a common condition afflicting up to 1% to 3% of the population worldwide (Rasmussen & Eisen, 1994). Its hallmark signs and symptoms include repetitive cognitive intrusions (Le., obsessions) and repetitive behaviors (Le., compulsions), as well as affective accompaniments (Le., anxiety; American Psychiatric Association, 1994). Although the current diagnostic scheme classifies OCD as an anxiety disorder, many investigators are inclined to focus on a so-called OC spectrum of disorders that share the commonality of repetitive symptoms (Hollander, 1993; McElroy, Phillips, & Keck, 1994). A medical model dictates that the classification of psychiatric disorders should reflect their respective underlying pathophysiologies. Unfortunately, contemporary psychiatric neuroscience data cannot yet fully support such an approach. OCDs are no exception in this regard, as the neural mechanisms underlying OCDs remain incompletely understood. Delineating pathophysiology represents a critical step toward improving diagnosis and treatment of psychiatric disease. Toward that end, there is great value in developing testable hypotheses regarding the pathophysiology of psychiatric diseases and proceeding to test them.

Original languageEnglish (US)
Title of host publicationObsessive-Compulsive Disorder
Subtitle of host publicationContemporary Issues in Treatment
PublisherTaylor and Francis
Number of pages22
ISBN (Electronic)9781317200239
ISBN (Print)0805828370, 9781138674783
StatePublished - Jan 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • General Psychology


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