TY - JOUR
T1 - Investigating Sex Differences in Emotion Recognition, Learning, and Regulation Among Youths With Conduct Disorder
AU - Kohls, Gregor
AU - Baumann, Sarah
AU - Gundlach, Malou
AU - Scharke, Wolfgang
AU - Bernhard, Anka
AU - Martinelli, Anne
AU - Ackermann, Katharina
AU - Kersten, Linda
AU - Prätzlich, Martin
AU - Oldenhof, Helena
AU - Jansen, Lucres
AU - van den Boogaard, Lisette
AU - Smaragdi, Areti
AU - Gonzalez-Madruga, Karen
AU - Cornwell, Harriet
AU - Rogers, Jack C.
AU - Pauli, Ruth
AU - Clanton, Roberta
AU - Baker, Rosalind
AU - Bigorra, Aitana
AU - Kerexeta-Lizeaga, Iñaki
AU - Sesma-Pardo, Eva
AU - Aguirregomoscorta-Menéndez, Fernando
AU - Siklósi, Réka
AU - Dochnal, Roberta
AU - Kalogerakis, Zacharias
AU - Pirlympou, Mara
AU - Papadakos, Leonidas
AU - Dikeos, Dimitris
AU - Hervas, Amaia
AU - Herpertz-Dahlmann, Beate
AU - Fernández-Rivas, Aranzazu
AU - Popma, Arne
AU - Stadler, Christina
AU - De Brito, Stephane A.
AU - Blair, James R.
AU - Freitag, Christine M.
AU - Fairchild, Graeme
AU - Konrad, Kerstin
N1 - Funding Information:
This study was funded by the European Commission's Seventh Framework Programme (FP7/2007-2013) under Grant Agreement no.602407 (FemNAT-CD, coordinator: Christine M. Freitag, MD, University Hospital Frankfurt). The funding source had no role in the study design, collection, analysis, or interpretation of data, the writing of the article, or decision to submit the article for publication.Disclosure: Prof. Dikeos has received speaker fees and served as a consultant to Angelini, AstraZeneca, Boehringer, Bristol Myers Squibb, Eli Lilly and Co., Genesis Pharma, GlaxoSmithKline, Janssen, Lundbeck, Organon, Sanofi, Servier, UniPharma, and Wyeth. Prof. Stadler has received royalties for a book on aggression. Dr. De Brito has received speaker fees from the Child Mental Health Centre and the Centre for Integrated Molecular Brain Imaging. Prof. Freitag has received royalties for books on ADHD, ASD, and depression. She has served as a consultant to Desitin and Roche. Prof. Konrad has received speaker fees from Shire Pharmaceuticals and Medice. Drs. Kohls, Scharke, Kersten, Jansen, Smaragdi, Gonzalez-Madruga, Rogers, Baker, Bigorra, Kerexeta-Lizeaga, Sesma-Pardo, Aguirregomoscorta-Menéndez, Siklósi, Dochnal, Hervás, Herpertz-Dahlmann, Fernández-Rivas, Popma, Blair, and Fairchild, Mss. Baumann, Gundlach, Bernhard, Martinelli, Ackermann, Mr. Prätzlich, Mss. Oldenhof, van den Boogaard, Cornwell, Pauli, Clanton, Mr. Kalogerakis, Ms. Pirlympou, and Mr. Papadakos have reported no biomedical financial interests or potential conflicts of interest.
Funding Information:
This study was funded by the European Commission's Seventh Framework Programme ( FP7 /2007-2013) under Grant Agreement no.602407 (FemNAT- CD , coordinator: Christine M. Freitag, MD, University Hospital Frankfurt). The funding source had no role in the study design, collection, analysis, or interpretation of data, the writing of the article, or decision to submit the article for publication.
Publisher Copyright:
© 2019 American Academy of Child and Adolescent Psychiatry
PY - 2020/2
Y1 - 2020/2
N2 - Objective: Conduct disorder (CD) is a serious neurodevelopmental disorder marked by notably higher prevalence rates for boys than girls. Converging evidence suggests that CD is associated with impairments in emotion recognition, learning, and regulation. However, it is not known whether there are sex differences in the relationship between CD and emotion dysfunction. Prior studies on emotion functioning in CD have so far been underpowered for investigating sex differences. Therefore, our primary aim was to characterize emotion processing skills in a large sample of girls and boys with CD compared to typically developing controls (TDCs) using a comprehensive neuropsychological test battery. Method: We included 542 youths with CD (317 girls) and 710 TDCs (479 girls), 9 to 18 years of age, from a European multisite study (FemNAT-CD). Participants completed three experimental tasks assessing emotion recognition, learning, and regulation, respectively. Data were analyzed to test for effects of group and sex, and group-by-sex interactions, while controlling for potentially confounding factors. Results: Relative to TDCs, youths with CD showed impaired emotion recognition (that was related to more physical and proactive aggression, and higher CU traits), emotional learning (specifically from punishment), and emotion regulation. Boys and girls with CD, however, displayed similar impairments in emotion processing. Conclusion: This study provides compelling evidence for a relationship between CD and deficient neurocognitive functioning across three emotional domains that have previously been linked to CD etiology. However, there was no support for sex-specific profiles of emotion dysfunction, suggesting that current neurocognitive models of CD apply equally to both sexes.
AB - Objective: Conduct disorder (CD) is a serious neurodevelopmental disorder marked by notably higher prevalence rates for boys than girls. Converging evidence suggests that CD is associated with impairments in emotion recognition, learning, and regulation. However, it is not known whether there are sex differences in the relationship between CD and emotion dysfunction. Prior studies on emotion functioning in CD have so far been underpowered for investigating sex differences. Therefore, our primary aim was to characterize emotion processing skills in a large sample of girls and boys with CD compared to typically developing controls (TDCs) using a comprehensive neuropsychological test battery. Method: We included 542 youths with CD (317 girls) and 710 TDCs (479 girls), 9 to 18 years of age, from a European multisite study (FemNAT-CD). Participants completed three experimental tasks assessing emotion recognition, learning, and regulation, respectively. Data were analyzed to test for effects of group and sex, and group-by-sex interactions, while controlling for potentially confounding factors. Results: Relative to TDCs, youths with CD showed impaired emotion recognition (that was related to more physical and proactive aggression, and higher CU traits), emotional learning (specifically from punishment), and emotion regulation. Boys and girls with CD, however, displayed similar impairments in emotion processing. Conclusion: This study provides compelling evidence for a relationship between CD and deficient neurocognitive functioning across three emotional domains that have previously been linked to CD etiology. However, there was no support for sex-specific profiles of emotion dysfunction, suggesting that current neurocognitive models of CD apply equally to both sexes.
KW - FemNAT-CD
KW - callous-unemotional traits
KW - conduct disorder
KW - emotion processing
KW - sex differences
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U2 - 10.1016/j.jaac.2019.04.003
DO - 10.1016/j.jaac.2019.04.003
M3 - Article
C2 - 31026574
AN - SCOPUS:85071985460
SN - 0890-8567
VL - 59
SP - 263
EP - 273
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 2
ER -