Investigation of effectiveness of microbubble stable cavitation in thrombolysis

William T. Shi, Shunji Gao, Vignon Francois, Jeff E. Powers, Lucas Drvol, Ki Won Jung, Feng Xie, John Lof, E. Carr Everbach, Thomas R. Porter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

Ultrasound and intravenous microbubbles have been used in recanalizing intravascular thrombi which cause ischemic stroke, myocardial infarction, and other vascular thrombo-embolic events. In previous studies, inertial cavitation (IC) produced by high mechanical index (MI) ultrasound has been shown to be effective in dissolving acute thrombi. However, IC is more likely to cause adverse bioeffects than stable cavitation (SC). This study indicates that SC induced by intermediate MI ultrasound (1.6 MHz, 0.35 MI, 50 cycles) is as effective for acute thrombus dissolution as IC by high MI ultrasound (1.6 MHz, 1.1 MI, 2.5 cycles).

Original languageEnglish (US)
Title of host publication2010 IEEE International Ultrasonics Symposium, IUS 2010
Pages330-333
Number of pages4
DOIs
StatePublished - 2010
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Conference

Conference2010 IEEE International Ultrasonics Symposium, IUS 2010
CountryUnited States
CitySan Diego, CA
Period10/11/1010/14/10

Keywords

  • microbubbles
  • sonothrombolysis
  • ultrasound therapy

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Shi, W. T., Gao, S., Francois, V., Powers, J. E., Drvol, L., Jung, K. W., Xie, F., Lof, J., Everbach, E. C., & Porter, T. R. (2010). Investigation of effectiveness of microbubble stable cavitation in thrombolysis. In 2010 IEEE International Ultrasonics Symposium, IUS 2010 (pp. 330-333). [5935628] (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2010.5935628