Investigation of image-guided sonothrombolysis in a porcine acute ischemic stroke model

William T. Shi, Thomas R. Porter, Francois Vignon, Jeffry E. Powers, Shunji Gao, Jinjin Liu, Feng Xie, Lucas Drvol, John Lof, E. Carr Everbach

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Image-guided sonothrombolysis was prototyped on a modified ultrasound imaging system iE33 and further evaluated using a porcine acute ischemic stroke model. After 20 to 40 minute sonothrombolysis treatment with systemic infusion of Definity microbubbles, contrast reperfusion and arterial recanalization were observed on low MI ultrasound contrast imaging and X-ray based angiography, respectively. The study indicates that a modified diagnostic imaging system can be utilized with systemic microbubble infusion to rapidly restore cerebral blood flow in acute ischemic stroke.

Original languageEnglish (US)
Title of host publication2011 IEEE International Ultrasonics Symposium, IUS 2011
Pages5-8
Number of pages4
DOIs
StatePublished - 2011
Event2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
Duration: Oct 18 2011Oct 21 2011

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2011 IEEE International Ultrasonics Symposium, IUS 2011
CountryUnited States
CityOrlando, FL
Period10/18/1110/21/11

Keywords

  • cavitation
  • microbubbles
  • sonothrombolysis

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Shi, W. T., Porter, T. R., Vignon, F., Powers, J. E., Gao, S., Liu, J., Xie, F., Drvol, L., Lof, J., & Everbach, E. C. (2011). Investigation of image-guided sonothrombolysis in a porcine acute ischemic stroke model. In 2011 IEEE International Ultrasonics Symposium, IUS 2011 (pp. 5-8). [6293205] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2011.0002