Investigation of ligand-receptor systems by high-resolution solid-state NMR: Recent progress and perspectives

Sorin Luca, Henrike Heise, Adam Lange, Marc Baldus

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Solid-state Nuclear Magnetic Resonance (NMR) provides a general method to study molecular structure and dynamics in a non-crystalline and insoluble environment. We discuss the latest methodological progress to construct 3D molecular structures from solid-state NMR data obtained under magic-angle-spinning conditions. As shown for the neurotensin/NTS-1 system, these methods can be readily applied to the investigation of ligand-binding to G-protein coupled receptors.

Original languageEnglish (US)
Pages (from-to)217-228
Number of pages12
JournalArchiv der Pharmazie
Volume338
Issue number5-6
DOIs
StatePublished - Jun 2005
Externally publishedYes

Keywords

  • GPCR
  • Ligand
  • MAS
  • NMR
  • Solid state

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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