Abstract
Solid-state Nuclear Magnetic Resonance (NMR) provides a general method to study molecular structure and dynamics in a non-crystalline and insoluble environment. We discuss the latest methodological progress to construct 3D molecular structures from solid-state NMR data obtained under magic-angle-spinning conditions. As shown for the neurotensin/NTS-1 system, these methods can be readily applied to the investigation of ligand-binding to G-protein coupled receptors.
Original language | English (US) |
---|---|
Pages (from-to) | 217-228 |
Number of pages | 12 |
Journal | Archiv der Pharmazie |
Volume | 338 |
Issue number | 5-6 |
DOIs | |
State | Published - Jun 2005 |
Externally published | Yes |
Keywords
- GPCR
- Ligand
- MAS
- NMR
- Solid state
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery