Investigation of retroviral involvement in chronic fatigue syndrome.

T. M. Folks, W. Heneine, A. Khan, T. Woods, L. Chapman, L. Schonberger

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Within the last few years significant efforts have been made to identify objective reliable diagnostic markers from individuals with chronic fatigue syndrome (CFS). We report the absence of a previously described retroviral marker (HTLV-II gag) in a blinded study of CFS cases. Even with excellent reproducible sensitivities, this marker failed in repeated attempts to distinguish cases from controls. In addition, four other retroviruses (simian T cell leukaemia virus, human spumavirus, bovine leukaemia virus and simian retrovirus) were examined for their presence in these CFS cases and found to be absent. Our findings suggest that these agents, at least as markers, are non-distinguishing for CFS and that other factors may be confounding the resolution of an aetiology to this syndrome.

Original languageEnglish (US)
Pages (from-to)160-166; discussion 166-175
JournalCiba Foundation symposium
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • General


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